Controlling Post-extraction Complications of Impacted Mandibular Third Molar

Methylprednisolone and Hyaluronic Acid Versus Each Agent Alone to Control Post-extraction Complications of Impacted Mandibular Third Molar

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04816253

Enrollment

Registered

2021-03-25

Start date

2021-02-10

Completion date

2021-06-20

Last updated

2021-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preventing Postextraction Complication

Brief summary

Impacted mandibular 3rd molar will be extracted in all patients, then patients will be divided, according to material placed in extraction socket into 3 groups: control, hyaluronic acid and honey. Then post extraction complications will be evaluated

Detailed description

Impacted Mandibular third molar will be extracted under local anesthesia Through standard surgical flap elevation, after extraction and wound irrigation a material facilitate healing will be placed. According to material will be placed patients will be divide into 3 group: control ( no material, second group hyaluronic acid, third group ( honey).. then wound will be closed. Postoperative pain ( through visual analog scale) , edema, total dose of analgesic, mandibular movement (interincisal distance in mm) will be evaluated preoperative, 1,2,3,7, and 10 day after extraction

Interventions

DRUGNormal saline

Normal saline irrigation and No other drug placed after extraction

DRUGHyaluronic acid

Immediately after removal of impacted tooth (hyaluronic acid) placed in extraction socket

DRUGMethylprednisolone

Methylprednsolone will be injected half an hour preoperatively

DRUGMethylprednisolone and Hyaluronic acid

Methylprednisolone will be injected half an hour preoperatively and Immediately after removal of impacted tooth (hyaluronic acid) placed in extraction socket

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy patients * patient has impacted 3rd molar

Exclusion criteria

* medically compromised patients Heavy smoking patients

Design outcomes

Primary

Measure	Time frame	Description
Interincisal distance	Baseline (Preoperative)	Measuring distance between upper lower anterior teeth in mm
Assessment of pain using Visual analog scale	Baseline (Preoperative)	Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain
Total amount of analgesic	1st day postoperative	Total amount of analgesic Will be calculated
Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle	Baseline	Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively

Countries

Saudi Arabia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026