Petroleum Product Toxicity
Conditions
Brief summary
The aim of this study is to assess the liver and renal functions of individuals who are occupationally exposed to petroleum products.
Detailed description
Certain peoples have a greater risk of exposure to gasoline vapors; these include filling-station workers, service station attendants, drivers of gasoline trucks and refinery workers.Benzene is metabolized in the liver by cytochrome P450 (CYP) 2E1 to benzene oxide. The metabolites undergo further metabolism through oxidation, dehydrogenation or conjugation with sulfate or glucuronic acid . Activation of benzene and its reactive metabolites leads to continuous production of reactive oxygen species (ROS), which leads to lipid peroxidation and damages DNA, RNA, leading to genetic modification and alterations in the functions of important enzymes (i.e. liver) and proteins . Volatile organic compounds such as gasoline and other fuels are associated with a wide variety of deleterious health effects including liver and kidney diseases. A comparative cross sectional study was conducted from January 2018 to April 2018 at Mekelle city, Tigray region, Northern Ethiopia among gasoline station workers and reporting that the mean level of ALT, AST, Urea, creatinine, and uric acid was significantly higher among gasoline stations workers when compared to control study participants and there was also a significant increase in ALT, AST, Urea, creatinine and uric acid among gasoline stations with increase duration of exposure .
Interventions
DIAGNOSTIC_TESTLiver function tests.
serum alanine amino transferase (ALT), aspartate amino transferase (AST), albumin (ALB), alkaline Phosphatase (ALP), total bilirubin.
DIAGNOSTIC_TESTkidney function tests
creatinine , urea and serum uric acid will be analysed in the serum.
Sponsors
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
for exposed group: * Apparently health workers who exposed for petroleum products in The Petroleum Pipelines Company in assiut will be included in the study
Exclusion criteria
for exposed and Comparison groups * history of hepatic and renal health problem * history of taking medications affecting liver and renal function tests
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| measurement of serum alanine amino transferase (ALT) in study participants. | 6 months | Number of participants with abnormal findings in serum alanine amino transferase (ALT) will be reported. |
| measurement of serum aspartate amino transferase (AST) in study participants. | 6 months | Number of participants with abnormal findings in serum aspartate amino transferase (AST) will be reported. |
| measurement of serum total bilirubin in study participants. | 6 months | Number of participants with abnormal findings in serum total bilirubin will be reported. |
| measurement of serum albumin (ALB) in study participants. | 6 months | Number of participants with abnormal findings in serum albumin (ALB) will be reported. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of serum urea in study participants. | 6 months | Number of participants with abnormal findings in serum urea will be reported. |
| Measurement of serum Creatinine in study participants. | 6 months | Number of participants with abnormal findings in serum Creatinine will be reported. |
Contacts
Primary ContactShimaa A. Mohammed, Lecturer
Backup ContactMarwa K. Abdo, Assist.Prof
Outcome results
None listed