Nephroblastoma (Wilms Tumour)
Conditions
Keywords
paediatric, oncology, kidney, DWI, MRI, nephroblastoma, Wilms tumour, quantitative estimation
Brief summary
Initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3T MR scanner or 1.5T MR scanner. A standard MRI study of the abdomen with contrast enhancement is performed. DWI (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps. Then, using Philips workstation (ISP 9.0, Philips, Netherlands), DWI mapping and ADC values collection (mm2/s) are performed. The placement of region of interest (ROI) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2. After the preoperative abdomen MRI, a surgical treatment is performed. Histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). The data is entered into the database and the relationship between ADC values and histological degrees of malignancy of nephroblastoma is investigated
Detailed description
Initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3T MR scanner or 1.5T MR scanner, using 8-channel body coil. A standard MRI study of the abdomen with contrast enhancement is performed. DWI (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps (DWI 3b) with 3 b-factors (50; 600; 800 or others, optional). Then, using Philips workstation (ISP 9.0, Philips, Netherlands), DWI mapping and ADC values collection (mm2/s) are performed. The placement of region of interest (ROI) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2. The values are entered in the table due to the stage of the chemotherapy. After the preoperative abdomen MRI, a surgical treatment is performed. Histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). The data is entered into the database and the relationship between ADC values and histological degrees of malignancy of nephroblastoma is investigated.
Interventions
DIAGNOSTIC_TESTMRI DWI sequence (ADC values)
Initially and after pre-operative chemotherapy To evaluate the differences in ADC values according to the malignancy degree of nephroblastoma in children
Sponsors
Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Days to 18 Years
Healthy volunteers
No
Inclusion criteria
1. Age under 18 y.o.; 2. Renal mass with confirmed histology.
Exclusion criteria
1. Absolute contraindications to magnetic resonance imaging (pacemaker, ferromagnetic implants, etc.); 2. Refusal to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the differences in ADC values according to the malignancy degree of nephroblastoma in children | Point 1. 15 ± 3 days Before the start of therapy - the starting point. |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the reproducibility and compatibility of the ADC values measurement; | Point 1. 15 ± 3 days Before the start of therapy - the starting point. |
| To assess the sensitivity and specificity of the MRI DWI sequence (ADC values) in the diagnosis of the malignancy degrees of nephroblastomas in children; | Point 1. 15 ± 3 days Before the start of therapy - the starting point. |
| To estimate the differences in ADC values within the intermediate degree of nephroblastoma malignancy in children | Point 1. 15 ± 3 days Before the start of therapy - the starting point. |
| To assess the ADC values change in depending according to the provided chemotherapy. | Point 1. 15 ± 3 days Before the start of therapy - the starting point. |
Countries
Russia
Contacts
Primary ContactEvelina f Nazarova
Outcome results
None listed