Neutropenic Enterocolitis
Conditions
Keywords
NEC, bed side ultrasound, diagnosis, treatment
Brief summary
Neutropenic enterocolitis (NEC) is a life-threatening complication of leukemic and solid tumors patients (pts) treated with chemotherapy (CHT) with high mortality rate up to 50-100%. Perforation occurs in 5%-10% of cases. Early diagnosis is crucial to start conservative medical management (CMM), which appears the optimal strategy for most cases. NEC should be always suspected in Neutropenic pts with abdominal pain, fever and diarrhea. Ultrasound (US) can be used to evaluate bowel-wall thickening (BWT). The objective of this study is to evaluate prospectively if US can detect early signs of NEC and guide a prompt treatment (CMM or surgical) and thus reduce mortality.
Interventions
DIAGNOSTIC_TESTBed side Ultrasound Sonography
Bed side Ultrasound in Neutropenic patients within 12 h from onset of any symptom such as fever and/or abdominal pain and/or diarreha
Sponsors
Azienda Ospedaliero, Universitaria Pisana
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All patients admitted in Hematology Ward University of Pisa (Italy) to receive chemotherapy who experienced neutropenia related to chemotherapy
Exclusion criteria
Patients admitted in Hematology Ward University of Pisa (Italy) who did not receive chemotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| to verify the hypothesis that US could detect early signs of NEC, guide a prompt treatment eventually reducing mortality | from March 2007 to January 2018 | Bed side Ultrasound sonography assessment of bowel in neutropenic patients with fever and/or abdominal pain and/or diarrhea |
| to correlate patient's symptoms with outcome | from March 2007 to January 2018 | Statistical correlation of symptoms with outcome |
| to verify if bowel wall thickening (BWT) is pathognomonic of neutropenic enterocolitis | from March 2007 to January 2018 | Comparison of bowel wall thickness in patients with diagnosis of neutropenic enterocolitis and in the control group (NEC negative group) |
| to find which symptom or symptoms have a higher relative risk (RR) for NEC diagnosis | from March 2007 to January 2018 | Statistical analysis of symptoms in the NEC group at diagnosis |
Countries
Italy
Outcome results
None listed