Psoriasis
Conditions
Brief summary
The aim of the study is to evaluate the effect of NB-UVB versus MTX on serum TWEAK level in psoriatic patients.
Interventions
RADIATIONNarrowband ultraviolet B
Patients will receive 8 sessions of NB-UVB per month for 3 successive months
DRUGMethotrexate
Patients will receive 25 mg/1ml of methotrexate vial per week for 3 successive months
Sponsors
Aswan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients with moderate to severe plaque psoriasis of any age and gender.
Exclusion criteria
* History of psoriasis treatment with systemic and biological agents prior to the study for at least 3 months. * Pregnancy and lactation. * Infections * Patients with chronic diseases: hepatic disorders, hematologic disease, chronic renal failure or cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum TWEAK in psoriasis | 3 months | Measurement of tumor necrosis factor weak inducer of apoptosis (TWEAK) pg/ml; in psoriatic patients before and after treatment with NB-UVB versus MTX in comparison with healthy individuals, using ELISA (enzyme-linked immunosorbent assay). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Treatment of psoriasis | 3 months | Clinical evaluation: Assessment of disease severity will be performed by using psoriasis area severity index (PASI score) before and after treatment with NB-UVB in comparison with MTX. Patients will be photographed at baseline and after 3 months of regular treatment by using high resolution digital camera canon EOS 1300D 18 megapixels (made in taiwan), photography will be done in standard light and distance. |
Countries
Egypt
Outcome results
None listed