Intractable Epilepsy
Conditions
Keywords
Event-related Potentials (ERP), Intracerebral recordings, Presurgical evaluation
Brief summary
Neurophysiologic evaluation of disorders of consciousness (DOC) patients in intensive care unit include late auditory evoked potentials. It allows the physicians to record cerebral responses of patients to auditory stimuli and in particularly to their own name (as the P3a response). Numerous studies try to improve the relevance of the auditory stimuli used in this paradigm and notably using more expressive stimuli. Here the investigators investigate the intracerebral correlates of the P3a responses recorded on the scalp with neutral and more expressive stimuli.
Detailed description
Late auditory evoked potentials (as P3 wave) are used in neurophysiology to assess the level of consciousness in DOC (disorder of consciousness) patients. The P3 wave, elicited by listening standard and deviant stimuli, corresponds to the activation of a frontoparietal network and is considered to reflect a cognitive attention task. Using the own name of the patient as deviant stimuli improve the ability to detect the P3 wave because of the particularly relevance of this stimulus for the patient. In human cognition, to identify the expressivity valence of a voice is essential. Neural processing of expressive voices should involves more widespread brain areas than neutral voices processing. Here the investigators investigate the intracerebral correlates of the P3a responses recorded on the scalp to own-name stimuli uttered by neutral and more expressive voices (positive : smiling voice or negative : rough voice) in adult pharmacoresistant epilepsy patients.
Interventions
Evoked related potentials are performed for each patient during each paradigm (neutral voice and expressive voices): * with scalp electrodes in the department of neurophysiology * with intracranial electrodes in the department of neurosurgery.
Sponsors
Centre Hospitalier St Anne
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Open and prospective study. Evoked related potentials are recorded on the scalp and with intracranial electrodes for each participant while they listen 3 paradigms successively and in a random order: i) their own name uttered by a smiling voice ii) their own name uttered by a neutral voice iii) their own name uttered by a rough voice
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Intractable focal epilepsy with undergoing pre-surgical evaluation * intracerebral electrodes implantation in auditory cortices, temporal lobe, superior temporal gyrus, limbic areas, frontal lobe * Given Consent to inclusion
Exclusion criteria
* Deafness * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Latencies cartography of intracranial responses to own-name uttered by neutral voice | 1 year | Analyse of latencies of intracranial responses recorded to own-name uttered by neutral voice to build a map of the brain process of this responses |
| Latencies cartography of intracranial responses to own-name uttered by expressive voices | 1 year | Analyse of latencies of intracranial responses recorded to own-name uttered by expressive voices to build a map of the brain process of this responses |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison between brain responses to own-name uttered by expressive voices recorded with intracerebral electrodes versus scalp electrodes | 1 year | Qualitative comparison between scalp and intracranial recordings with the expressive voices paradigms (comparison of the latencies of the recorded responses) |
| Comparison between brain responses to own-name uttered by neutral voices recorded with intracerebral electrodes versus scalp electrodes | 1 year | Qualitative comparison between scalp and intracranial recordings with the neutral voices paradigms (comparison of the latencies of the recorded responses) |
Countries
France
Outcome results
None listed