Healthy
Conditions
Brief summary
The purpose of this research is to establish the normal range of diameter and distensibility of pylorus and the fasting and postprandial antro-pyloric motility in healthy adults.
Detailed description
An Endoflip catheter will be placed through the mouth into the stomach in order to measure distal antral contractile activity and pyloric diameter and distensibility during fasting and after the ingestion of a standard meal
Interventions
DIAGNOSTIC_TESTEndoflip measurement of gastric and pyloric function
Endoflip device to measure gastric and pyloric functions
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Females and males. * Between the ages of 18 and 65 years. * Body mass index between 18 and 35 kg/m\^2.
Exclusion criteria
* Heartburn, regurgitation, or symptoms suggestive of gastroparesis such as nausea, early satiety, postprandial bloating, and upper abdominal pain. * Pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fasting and postprandial pyloric diameter | 1 hour prior to meal and 1 hour following standardized meal | Change in Pyloric diameter will be measured during fasting and postprandial using Endoflip |
| fasting and postprandial pyloric distensibility index | 1 hour prior to meal and 1 hour following standardized meal | Change in Pyloric distensibility index will be measured during fasting and postprandial using Endoflip |
| fasting and postprandial distal antral motility index | 1 hour prior to meal and 1 hour following standardized meal | Change in distal antral motility index will be measured during fasting and postprandial using Endoflip |
Countries
United States
Outcome results
None listed