Obesity Female Patients Require General Anaesthesia With Intubation and Atracurium Curarization
Conditions
Keywords
Tracheal intubation, Atracurium
Brief summary
The purpose of this study is to evaluate intubation conditions with the use of atracurium after a fixed three-minute delay
Detailed description
The recommended dose of a non-depolarizing curare to facilitate tracheal intubation is twice the active dose 95 (the dose that reduces muscle force by 95%). At this dosage, curarization of the laryngeal adductors allowing relaxation and abduction (opening) of the vocal cords is considered certain. With atracurium, the dose for intubation is 0.5 mg.kg-1 and the time to full effect is approximately 3 minutes. With the use of newer hypnotics, there are no data evaluating the conditions for intubation after a fixed time of 3 minutes as with current anesthetic practices.
Interventions
None listed
Sponsors
URC-CIC Paris Descartes Necker Cochin
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult female * Patient to undergo general anesthesia with intubation for scheduled gynecological surgery * Patient informed about the study and not opposed to it
Exclusion criteria
* Patients with severe and morbid obesity (BMI\>35kg/m2) * Pregnancy * Patients with difficult intubation * Allergy to atracurium and to any other drug used. * Patient under tutorship / curatorship * Not affiliated with social insurance * Patient with AME
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intubation condition | 3 minutes after atracurium injection | The intubating conditions were evaluated on the basis of the consensus conference on Good Clinical Research Practice in Pharmacodynamic Studies of Neuromuscular Blocking Agents. The score used include the following variables: (1) ease of laryngoscopy, (2) vocal cord position, and (3) reaction to the insertion of the endotracheal tube and the cuff inflation (eg, diaphragmatic movement due to patient cough). Each of these variables was rated as (1) excellent, (2) good, or (3) poor. Intubating conditions were scored as excellent if all variables were excellent; the score was good if at least 1 variable was good and the rest were excellent; the conditions were considered poor if any of the variables was rated poor. Evaluation of intubation conditions with the use of atracurium after a fixed three-minute delay |
Countries
France
Outcome results
None listed