Desflurane, Propofol, Postoperative Sleep, PSQI, Breast Tumor
Conditions
Brief summary
This study intends to investigate the effects of desflurane on postoperative sleep quality to guide perioperative patient management.
Interventions
Subjects were randomized in a 1:1 ratio to undergo breast surgery under maintenance of anesthesia with the classical intravenous anesthetic drug propofol (reference group) or the inhaled anesthetic drug desflurane (test group).
Sponsors
Zhongnan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. Undergoing elective breast surgery 2. Age 18-75 years old 3. ASA-PS grade I or II 4. Those who voluntarily participate in the research and sign the informed consent
Exclusion criteria
1. Cognitive impairment (MMSE \<27) before the operation 2. The patients received adjuvant chemotherapy before the operation 3. At present, they are taking psychoactive, opioid, anti-anxiety, and hypnotic drugs 4. Known or treated patients with obstructive sleep apnea 5. Patients with other cancers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh sleep quality index | Postoperative 3rd day |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pittsburgh sleep quality index | Postoperative 7th, and 30th days | — |
| Total sleep time (TST), Rapid eye movement time (REM), Wakefulness after sleep onset (WASO) | Postoperative 1st, 2nd, and 3rd days | Fitbit Charge 2™ objectively measured |
| Self-Rating Anxiety Scale Scores | Postoperative 3rd, 7th, and 30th days | — |
| Recovery time and quality (steward scores) | Up to 2 hours after operation | — |
| Visual analogue scale scores | Postoperative 3rd, 7th and 30th days | — |
| Flurbiprofen dose | Postoperative 1st, 2nd, and 3rd days | — |
| Self-Rating Depression Scale Scores | Postoperative 3rd, 7th and 30th days | — |
Countries
China
Outcome results
None listed