Cardiovascular Risk Factor, Sleep
Conditions
Keywords
cardiovascular, sleep duration, vascular endothelial function
Brief summary
This is a cross-sectional study with an optional intervention that will examine how extreme sleep durations relate to cardiovascular health, physical activity, and sleep quality by studying three groups of participants: short sleepers (≤ 6 hrs), long sleepers (≥ 9 hrs), and average duration sleepers (7-8 hrs). The optional intervention asks participants to maintain an 8-hour per night regular sleep schedule for one week.
Detailed description
PRIMARY OBJECTIVES: 1\. To test the hypothesis that vascular endothelial function in the brachial artery, and other associated cardiovascular risk markers are impaired in short sleepers and long sleepers as compared to the control group of average duration sleepers. To test the hypothesis that the optional intervention to maintain an 8-hour per night sleep schedule will alleviate vascular endothelial function impairment. OUTLINE: Participants will measure sleep, physical activity, and blood pressure with at-home devices before coming in for one in-lab visit, where they will have vascular function and blood markers measured, as well as an optional CT scan to measure calcium in the coronary arteries. An optional intervention may occur after this: Participants will continue the at-home measures while maintaining a chosen regular 8-hour per night sleep schedule, before coming in for a second in-lab visit with all same measures except for CT scan.
Interventions
BEHAVIORALRegularized Sleep Schedule
Participants may maintain a self-selected 8-hour per night sleep schedule as an optional intervention. Participants from any of the three groups may complete the intervention.
Sponsors
Oregon Health and Science University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and women ages 25-65y * Lean and overweight (BMI 18.5-40 kg/m2) * No acute, chronic, or debilitating medical conditions * No prescription/non-prescription medications or drugs of abuse * Current non-smoker (tobacco and marijuana) * Persons who fit all the above criteria and are suitable based on a medical history and health habits questionnaire, and additional sleep and health profiling questionnaires may be eligible to participate.
Exclusion criteria
* Persons with any acute, chronic, or debilitating medical condition except pre-hypertension will be excluded. * Persons with any symptoms of acute or active illness (e.g. fever, leukocytosis) will be excluded. * Persons with a history of severe psychiatric illness or psychiatric disorders will be excluded. * Persons with a history of regular night/or rotating shift work in the past year, or who have traveled more than three time zones during the one month prior to the study will be excluded. * Pregnant women, decisionally impaired adults, and prisoners will be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular Endothelial Function | 2 weeks | Investigators will measure endothelial function as flow-mediated dilation. |
| Blood pressure | 2 weeks | Blood pressure (systolic and diastolic) will be measured in a supine position in the dominant arm. |
| Sleep duration | 2 weeks | Sleep duration will be scored from the ActiGraph and correlated with the sleep and activity diary. |
Countries
United States
Contacts
CONTACTNicole Chaudhary, MPH
PRINCIPAL_INVESTIGATORSaurabh S Thosar, PhD
Oregon Health and Science University
Outcome results
None listed