Air Travel
Conditions
Keywords
Air Travel, health
Brief summary
In the period from June 2021 to June 2022, a prospective clinical study will be conducted in the Republic of Kazakhstan with economy class passengers traveling by plane with a minimum flight period of 5-7 flight hours in the territory of the Republic of Kazakhstan.
Interventions
DRUGCiticoline
Citicoline 500 mg (Vitaae®) per os
DRUGCytochrome C6
Cytochrome10 mg per os
DRUGSodium Chloride Oral Product
Sodium Chloride (NaCl) 2.6 g. per os
Potassium Chloride 1.5 g per os
DRUGSodium Citrate Oral Product
Sodium Citrate 2.90 g per os
DRUGDextrose Oral Tablet, Chewable
Dextrose 13.5 g per os
Domperidone 1 tablet per os
DRUGSimethicone
3-4 capsules per os
DRUGAcetylsalicylic acid
Acetylsalicylic acid 150 mg per os
DRUGMagnesium hydroxide
magnesium hydroxide 30 mg per os
1 capsule per os.
DRUGMelatonin 5 mg
Melatonin 5 mg per os.
Sponsors
Dinara Zhumanbayeva
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
Study participants (Volunteers) will be recruited through media, advertisements and announcements. Prior to the study, study participants will receive written and oral explanations of the study protocols, and written informed consent will be obtained from each study participant. All potential research participants will undergo medical and psychological selection. The components, stages of selection are almost the same as those of general professional selection: the first stage is professiography / psychogram, the second stage is psychodiagnostics, the third stage is assessment and forecasting, and the fourth stage is decision making. Selection will assess the ability of participants to perform complex sequential actions. Inclusion criterion: * Age from 22 to 30 years old; * at least 15 years of education, including secondary education; * understand and speak Russian (Due to the valid Russian-language questionnaire and methodology). In addition, study participants will be asked not to limit their caffeine intake from their daily intake, but only water is allowed 4 hours before the neuropsychological testing. Participants in the study should not hmedical/medicallane in the last two weeks prior to the start of the study, nor should they consume alcohol during the study. Exclusion criterion: * A member taking melatonin (affects circadian rhythm); * Participant with comorbidities that affect cognitive function and sleep (eg, stroke, TIA, concussion with loss of consciousness, hearing problems, chronic fatigue syndrome, depression, seasonal affective disorder, anorexia); * A participant with another ongoing sleep disorder. All participants must be free of a history of venous thrombosis, antithrombotic or anticoagulant medications and oral contraceptives and / or any other drugs that interfere with blood coagulation (i.e. warfarin, coumadin) for at least 2 months prior to study initiation, and sign a consent to refrain from taking medications that may affect coagulation, such as aspirin or non-steroidal anti-inflammatory drugs, within 3 days after the flight, unless there is a medical / medical need. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuropsychological tests (Trail Making Test, Wechsler Memory Scale - IV, Free recall | 24 hours after the flight | Word, color, and color-word T-Scores of 40 or less are considered low. Word, color, and color-word T-Scores above 40 or are considered normal. In order for one score to be considered higher or lower than another, a 10 point or greater T score difference is required. |
| Urine Specific Gravity | 24 hours before the flight | Urine Specific Gravity test |
| SpO2 level | 24 hours before the flight | Pulse oximetry |
| Ultrasound examination | 24 hours before the flight | Ultrasound examination of the veins of the lower limbs |
| The Liverpool Jet Lag questionnaire | 24 hours before the flight | Changes from normal (0 to 5) while jetlag rating was recorded on a scale from 0 = insignificant jetlag to 10 = severe jetlag |
| Lake Louise Acute Mountain Sickness Assessment System | 24 hours before the flight | Mild acute mountain sicknessas 3-5 points, moderate acute mountain sickness as 6-9 points, and severe acute mountain sickness as 10-12 points |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lake Louise Acute Mountain Sickness Assessment System | 24 hours after the flight | Mild acute mountain sicknessas 3-5 points, moderate acute mountain sickness as 6-9 points, and severe acute mountain sickness as 10-12 points |
| The Stroop Test | 24 hours after the flight | Word, color, and color-word T-Scores of 40 or less are considered low. Word, color, and color-word T-Scores above 40 or are considered normal. In order for one score to be considered higher or lower than another, a 10 point or greater T score difference is required. |
| Urine Specific Gravity | 24 hours after the flight | Urine Specific Gravity test |
| SpO2 level | 24 hours before the flight | Pulse oximetry |
| The Liverpool Jet Lag questionnaire (LJLQ) | 24 hours after the flight | Changes from normal (0 to 5) while jetlag rating was recorded on a scale from 0 = insignificant jetlag to 10 = severe jetlag |
Contacts
Primary ContactArman Lurye
Backup ContactDinara Dzhumanbayeva
Outcome results
None listed