Alveolar Recruitment Manoeuver, Anesthesia
Conditions
Brief summary
Objective: to compare the effect of alveolar recruitment manouver through stepwise increase and decrease in airway pressure or sustained 30 secondes 30 cmH2O continuous positive airway pressure on cardiac stroke volume estimated by oesophageal doppler in preload independent anesthetized patients scheduled for surgery.
Detailed description
Following anesthesia and preload optimisation guided by cardiac stroke volume, patients will be randomised to one alveolr recruitment manoeuver : * stepwise increase and decrease in positive airway pressure * sustained 30 secondes 30 cmH2O continuous positive airway pressure The primary objective is the change in cardiac stroke volume.
Interventions
PROCEDUREalveolar recruitment manoeuver
alveolar recruitment manoeuver are recommended during general anesthesia to prevent pulmonary atelectasis
Sponsors
University Hospital, Caen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Caregiver)
Masking description
The patient will not know the allocation group because he will be anesthetised before randomisation. The care provider (anesthetist) will not know the allocation group because the intervention will be applied by an independent investigator not involved in care of the patient.
Intervention model description
randomised parallel groups. randomisation between 2 groups equilibated by randomised blocks of 4, 6 or 8
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patients scheduled for major surgery requiring hemodynamic monitoring * written signed informed consent
Exclusion criteria
* pregnancy * non sinusal heart rate * known cardiac right ventricular failure or arterial pulmonary hypertension * pneumothorax * known pulmonary emphysema
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiac stroke volume | 1 min | change in cardiac stroke volume during the alveolar recruitment manoeuver |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| arterial pressure | 1 min | change in arterial pressure during the alveolar recruitment manoeuver |
| recovery at 3 min | 3 min | recovery of cardiacstroke volume and arterial pressure 3 min after the end of alveolar recruitment manoeuver |
Countries
France
Outcome results
None listed