Matrix Metalloproteinase
Conditions
Keywords
biliary drainage, matrix metalloproteinases
Brief summary
The purpose of this study is to detect differences in the enzymatic activity of matrix metalloproteinases in patients with malignant obstructive hyperbilirubinemia before and after percutaneous biliary drainage.
Detailed description
This study will be designed as a prospective cohort study involving the collection of peripheral blood samples before and one month after percutaneous biliary drainage for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity). Biochemical analyzes are preceded by the entry of data relevant to the research (demographic, anamnestic, clinical and biochemical).
Interventions
PROCEDUREPercutaneous biliary drainage
Collection of peripheral blood samples before and one month after percutaneous biliary drainage performed for patients with malignant obstructive hyperbilirubinemia for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity).
Sponsors
Klinički centar Srbije
Institut za Rehabilitaciju Sokobanjska Beograd
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
pathological confirmation or imaging data confirming malignant disease causing bile duct obstruction, performance status 0-1
Exclusion criteria
terminally ill patients, performance status \>2, hepatic decompensation, severe underlying cardiac or renal diseases and coagulation disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MMP-2 and MMP-9 serum activity | during intervention | MMP serume activity will be measured by molecular biochemical analysis performed on peripheral blood samples taken before and one month after percutaneous biliary drainage |
Countries
Serbia
Contacts
Primary ContactAleksandar N Filipovic, Dr
Outcome results
None listed