Cardiometabolic Syndrome, Diet, Healthy, Hyperuricemia
Conditions
Keywords
Vegan diet, Uric acid, Cardiometabolic risk factors, Amla fruits
Brief summary
This is an intervention study aiming to test the effectiveness of a vegan diet, My Plate with low purine choices, and amla fruits on uric acid and other cardiometabolic risk factors in individuals with high serum uric acid levels.
Detailed description
Ninety-two participants with hyperuricemia will be randomly assigned to one of these 4 diet interventions: (1) vegan, (2) vegan with amla fruits, (3) my plate-low purine, (4) my plate-low purine with amla fruits. During the 3 months intervention phase, participants will attend group lessons and individual nutrition counseling sessions to assist adherence to the diet. At baseline, end of 3 months, and 1 year, participants will be measured on uric acid and other cardiometabolic risk factors, and some nutritional markers. Amla fruits powder, and some foods encouraged in each dietary arm will be provided to enhance adherence during the 3 months intervention phase.
Interventions
OTHERHealthy vegan diet
Participants will attend group lessons and individual nutrition counseling to help them adopt a healthy vegan diet.
OTHERMy Plate - Low Purine
Participants will attend group lessons and individual nutrition counseling to help them adopt a balanced diet in accordance with my plate, and emphasis on choosing low purine options from the protein food groups.
OTHERAmla fruits
Participants will be provided with powdered amla fruits, and will be instructed to take 3g per day.
Sponsors
Fu Jen Catholic University
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Men with serum uric acid \> 7mg/dL * Women with serum uric acid \> 6mg/dL * Willing to make diet changes according to dietary interventions
Exclusion criteria
* Age \<19 * With cancer diagnosis * With diseases that require special dietary needs * On urate-lowering medication within 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Uric acid | 3 months | Serum uric acid |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glucose metabolism | 3 months | fasting glucose |
| Lipid profile | 3 months | cholesterol |
| vitamin B12 | 3 months | serum vitamin B12 |
| Body mass index | 3 months | body mass index calculated from height and weight |
| homocysteine | 3 months | serum homocysteine |
| vitamin D | 3 months | serum 25(OH)D |
| holostranscobalamin | 3 months | serum holotranscobalamin |
Countries
Taiwan
Outcome results
None listed