Neonatal Sepsis
Conditions
Brief summary
To evaluate reliability of salivary C-reactive protein ,mean platelet volume , neutrophil -lymphocyte ratio , and platelet lymphocyte ratio in diagnosis of neonatal sepsis
Interventions
DIAGNOSTIC_TESTSalivary CRP
Salivary C reactive protein in neonatal sepsis
Sponsors
Cairo University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 28 Days
Healthy volunteers
Yes
Inclusion criteria
* \- Full term neonates of both genders from birth to the 28th day of life diagnosed with sepsis by history, clinical findings, laboratory findings, and blood culture. The clinical findings included the presence of three or more of the following: * (1) temperature instability (hypothermia, hyperthermia) . * (2) respiratory alterations (grunting, intercostal retractions, apnea, tachypnea, cyanosis) . * (3) cardiovascular alterations (bradycardia, tachycardia, poor perfusion, hypotension) . * (4) neurologic alterations (hypotonia, lethargy, seizures) * (5) gastrointestinal alterations (feeding intolerance, abdominal distension). CRP values \>10 mg/L were considered to be positive.
Exclusion criteria
* \- Preterm neonates . * Neonates with CNS malformations, metabolic disorders, chromosomal abnormalities, intrauterine growth restriction, or birth asphyxia were excluded from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Salivary c reactive protein in neonatal sepsis | 28 days | Salivary C reactive protein of value as non invasive procedure in diagnosis of neonatal sepsis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean platelet volume | 28 days | Asses the validity of Mean Platlet Volume as marker of neonatal sepsis which is equal about ( 9 - 11.4 ) in septic group and about ( 7.5 - 8.5 ) in control group |
Countries
Egypt
Outcome results
None listed