Lung Cancer, Morality, Surgery--Complications
Conditions
Keywords
non-small cell lung cancer, VATS lobectomy, 90-day postoperative mortality, risk score, validation
Brief summary
A five classes (A-E) aggregate risk score predicting 90-day mortality after video-assisted thoracoscopic lobectomy for lung cancer, including as independent factors male sex (3 points), carbon monoxide lung diffusion capacity \<60% (1 point) and operative time \>150 minutes (1 point), has been recently published. This study aims to assess the effectiveness and reliability of this risk model in a large, independent cohort of patients, in order to confirm its generalizability.
Detailed description
From the Italian VATS Group Database, we selected patients who underwent video-assisted thoracoscopic lobectomy for non-small cell lung cancer. We calculated the aggregate risk score and the corresponding class of 90-day mortality risk for each patient. The correlation between risk classes and mortality rates was tested by Spearman's rho-test. Model calibration was evaluated by Hosmer-Lemeshow goodness-of-fit test.
Interventions
PROCEDUREVATS lobectomy
VATS lobectomy
Sponsors
Università degli Studi dell'Insubria
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
\- Patients undergoing VATS lobectomy for non-small cell lung cancer
Exclusion criteria
* Incomplete data for risk score calculation * Tumor size \>5 cm * Follow-up \<3 months * Patients undergoing neoadjuvant treatment * Patients undergoing extended resection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 90-day postoperative mortality | 90 day post surgical procedure | Alive/Death (cause of death) |
Outcome results
None listed