Renal Cell Carcinoma
Conditions
Keywords
kidney cancer, partial nephrectomy, split renal function
Brief summary
The study aims to compare pre- and postoperative 3D renal function results of patients who underwent on-clamp and off-clamp partial nephrectomy.
Interventions
PROCEDUREOn-clamp partial nephrectomy
Partial nephrectomy will performed with renal artery clamping (less than or equal to 25 minutes)
PROCEDUREOff-clamp partial nephrectomy
Partial nephrectomy will performed without renal artery clamping
Sponsors
I.M. Sechenov First Moscow State Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1\. Men and women \>18 years; 2. Diagnosis of unilateral renal cell carcinoma (stage T1-T3aN0M0); 3. Planned surgery: retroperitoneoscopic/laparoscopic/robotic partial nephrectomy; 4. Patients with CT of the kidneys with contrast enhancement performed according to the required protocol. \-
Exclusion criteria
1. Age \< 18 years old or ASA\> 3; 2. Solitary kidney; 3. Bilateral kidney 4. The presence of concomitant systemic pathology (DM, AH), as well as kidney disease (glomerulonephritis), which can change the state of the renal parenchyma; 5. Obstructive nephropathy 6. Systemic intake of nephrotoxic drugs; 7. Pregnancy. -
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GFR after the surgery | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Complication rate (Clavien-Dindo) | 3 months |
Countries
Russia
Contacts
Primary ContactDmitry Fiev, M.D., Ph.D.
Backup ContactDmitry Enikeev, M.D., Ph.D.
Outcome results
None listed