PCO2 ELSO (Extracorporeal Life Support Organization)

Association Between Early Change in PaCO2 After ECMO Initiation and Neurological Outcome in Newborns

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04798794

Enrollment

4072

Registered

2021-03-15

Start date

2015-01-01

Completion date

2020-12-11

Last updated

2021-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Failure

Keywords

Ecmo, Neonates

Brief summary

Investigation of the association between PaCO2 change after extra corporeal membrane oxygenation (ECMO) initiation and neurological outcome and mortality in neonates treated by ECMO for respiratory failure.

Detailed description

Retrospective analysis of the ELSO database investigating the association between the change of PCO2 value after ECMO start and the risk of acute neurological event under ECMO defined by the onset of cerebral bleeding and/or ischemic stroke and/or clinical or electrical seizure and/or brain death.

Interventions

OTHERECMO for neonates

Neonates (\<28 j) supported by ECMO for severe respiratory failure

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Days to 28 Days

Healthy volunteers

Inclusion criteria

: * Support by ECMO for respiratory indication

Exclusion criteria

: * None

Design outcomes

Primary

Measure	Time frame	Description
Acute Neurological Event	Up to 90 days after ECMO initiation	Onset of cerebral bleeding and/or ischemic stroke and/or clinical or electrical seizure and/or brain death. The outcome (ANE) was defined by the occurrence of almost one of the following item: * Ischemic or hemmorrhagic stroke diagnosed by ultrasounds, CT or MRI * Clinical or electrical seizures : diagnosed by ElectroEncepahloGraphy (EEG) * Brain death clinically diagnosed

Secondary

Measure	Time frame	Description
28-day mortality	28 days after ECMO start	Newborns died after 28 days despite ECMO assistance

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026