Keratosis Pilaris
Conditions
Brief summary
Keratosis pilaris (KP) is a common disorder of keratinization. There are different treatment modalities for KP with variable results. Nd:YAG laser and chemical peels are among these treatment modalities, however, there is no enough evidence in the literature regarding their efficacy. The aim of this study is to assess and compare the efficacy of long pulsed Nd:YAG laser and trichloreacetic acid 20% in treatment of keratosis pilaris.
Detailed description
Keratosis pilaris (KP) is a genetic disorder of keratinization of hair follicles of skin. It's a very common benign condition that manifests as small, rough folliculocentric keratotic papules, often described as chicken bumps, chicken skin or goose-bumps, in characteristic areas of body, particularly the outer upper arms and thighs. Trichloreacetic acid (TCA) is a type of chemical peels that is derived from acetic acid by the chlorination of 3 hydrogen ions. It can induce coagulative necrosis of proteins and cells. The depth of action depends on various factors e.g the number of layers applied and its combination with substances that potentiate its action. Nd: YAG laser is a type of hair removing devices that operates at wave length of 1064nm. This wave length allows for less absorption at the epidermis. It is less absorbed by melanin, which leads to lower side effect and better tolerance but less efficacy in dark skinned patients.
Interventions
DEVICENd-YAG laser
laser hair removal device
DRUGTCA 20%
chemical peel
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients above 18 years with KP. * Patients with KP affecting back of the trunk, arms, thighs, forearms, legs and buttocks.
Exclusion criteria
* Pregnant or lactating females. * Patients who had performed any laser treatment for KP within 6 months prior to the study. * Patients with history of oral retinoids within 3 months prior to the study. * Patients with history of hypertrophic scars or keloids. * Patients who used any topical treatment one month prior to the session. * Patients with acne affecting the same sites of keratosis pilaris. * Patients with active skin diseases affecting the area involved with KP e.g. folliculitis and eczema.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of clinical and dermoscopic scores of KP with Nd-YAG laser | 4 months | the change in roughness and color of KP by clinical score after 4 sessions of Nd-YAG laser. the score ranges from 0-4. where 0 is no change and 4 is excellent improvement |
| Change of clinical and dermoscopic scores of KP with TCA 20% | 4 months | the change in roughness and color of KP by clinical score after 4 sessions of TCA 20% peel. the score ranges from 0-4. where 0 is no change and 4 is excellent improvement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| safety and tolerability of Nd-YAG laser and TCA 20% in treatment of KP: adverse events | 4 months | adverse effects of treatment modalities, if any |
Countries
Egypt
Outcome results
None listed