Necrotizing Enterocolitis, Neonate, Surgery
Conditions
Brief summary
Necrotizing enterocolitis(NEC) is one of the most serious disease in the newborn infants, and two and more grades of NEC usually lead to surgery, even death. But, it is difficult to predict when to operate the surgery.
Detailed description
Necrotizing enterocolitis(NEC) is characterized by vomit, abdominal distention, hypoactive bowel sounds and bloody stools, even shock, disseminated intravascular coagulation(DIC) and sepsis. X-ray is shown Intestinal wall gas and/or portal vein pneumatosis and pneumoperitoneum. Two and more grades of NEC in newborn infant is a urgent condition, and whether or not operation is difficult to predict. Here, the investigators develop a score system including five parameters(abdominal circumference, base excess, heart rate, severities of respiratory distress, sepsis) in one retrospective cohort, and the score system is used and assessed to predict the need for surgery in another prospective cohort.
Interventions
OTHERscore system to predict the need for surgery
two and more grades of NEC is assessed using the score system to predict the need for surgery
OTHERusual method to predict the need for surgery
two and more grades of NEC is assessed using the usual method to predict the need for surgery
Sponsors
Children's Hospital of Chongqing Medical University
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Hours to 44 Weeks
Healthy volunteers
No
Inclusion criteria
* two and more of NEC is diagnosed in the newborn infants * on the time of diagnosis for NEC both the surgery and non-surgery are reasonable according the surgeon's suggestions
Exclusion criteria
* pneumoperitoneum * refusing to take part in the study according to parents' decision
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sensitivity of the score system for predicting the need of surgery | before surgery | sensitivity of the score system for predicting the need of surgery is assessed |
| specificity of the score system for predicting the need of surgery | before surgery | specificity of the score system for predicting the need of surgery is assessed |
| accuracy of the score system for predicting the need of surgery | before surgery | accuracy of the score system for predicting the need of surgery is assessed |
| positive likelihood ratio of the score system for predicting the need of surgery | before surgery | positive likelihood ratio of the score system for predicting the need of surgery is assessed |
| negative likelihood ratio of the score system for predicting the need of surgery | before surgery | negative likelihood ratio of the score system for predicting the need of surgery is assessed |
| positive predictive value of the score system for predicting the need of surgery | before surgery | positive predictive value of the score system for predicting the need of surgery is assessed |
| negative predictive value of the score system for predicting the need of surgery | before surgery | negative predictive value of the score system for predicting the need of surgery is assessed |
Countries
China
Contacts
Primary ContactChen Long, MD, PhD
Outcome results
None listed