Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children

Clinical Features and Outcomes of Continuous Blood Purification Versus Non-continuous Blood Purification in Pediatric Patients With Sepsis or Septic Shock

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04794595

Enrollment

Registered

2021-03-12

Start date

2020-12-01

Completion date

2026-12-30

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Children, Only, Sepsis

Keywords

Continuous renal replacement therapy, sepsis, timing

Brief summary

The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored. In this study, we need to explore the efficacy and the timing of application of CBP in children with sepsis or septic shock.

Detailed description

Early intervention of CBP can remove inflammatory factors in patients with sepsis and reduce the damage of inflammatory factors to organs; at the same time, it can also promote the body's immune response, significantly improve immune dysfunction, and restore the body's immune balance. However, the timing of early application of CBP in childhood sepsis is still unclear. Therefore, it is necessary to further explore the treatment and prognosis of this technology in the early treatment of sepsis.

Interventions

PROCEDURECBP

continuous blood purification can prevent or treat fluid overload in children with septic shock or other sepsis-associated organ dysfunction who are unresponsive to fluid restriction and diuretic therapy management of septic AKI patients, particularly those with hemodynamic instability or fluid overload. Also, it can remove cytokines

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

28 Days to 18 Years

Healthy volunteers

Inclusion criteria

* Age of 29d to 18 years old; * Children diagnosed with sepsis requiring blood purification.

Exclusion criteria

* with a history of a duration of PICU stay \<24 h * active bleeding, including cerebral hemorrhage

Design outcomes

Primary

Measure	Time frame	Description
survival rate	28 days after hospital discharge	The survival rate of children in 28 days after hospital discharge

Secondary

Measure	Time frame	Description
The creatinine level of non-survival children with sepsis	28 days after hospital discharge	The creatinine level of non-survival children with sepsis in 28 days after hospital discharge

Countries

China

Contacts

CONTACTYING JIAYUN

jiayundoctor@163.com18817583962

PRINCIPAL_INVESTIGATORLu guoing

Children's Hospital of Fudan University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026