Involucrin, Verruca Vulgaris
Conditions
Brief summary
Vitamin D3 plays important role in keratinocyte differentiation and had been used recently in verruca vulgaris. Aim of the work: To assess the expression of involucrin in verrucae vulgaris before and after injection of vitamin D3. Subjects and Methods: This study included 60 patients with verrucae vulgaris subjected to intralesional injection of vitamin D3 at three weeks interval for a maximum of five sessions. Immunohistochemical assessment of involucrin was done before and after injection and compared to skin biopsies from 30 healthy individuals
Interventions
DRUGCholecalciferol
Cholecalciferol injection
Sponsors
Benha University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
Patients with multiple verruca vulgaris Patients with with verrucae vulgaris with size more than 3 cm
Exclusion criteria
Patients with a past history of allergic response to vitamin D. Pregnant or lactating females. Hepatic patients. Renal patients. Patients with bleeding tendency.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Resolution of verrucae | 3 months | Decrease of verrucae size Decrease of verrucae number |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Involucrin expression | 3 months | Change of expression pattern of involucrin by immunohistochemical study Change of expression grade of involucrin by immunohistochemical study |
Countries
Egypt
Outcome results
None listed