Covid19
Conditions
Keywords
vitamin D, Latin America, supplementation
Brief summary
The immunomodulatory effects of vitamin D are known to be beneficial in viral infections, it is also known that its deficiency is associated with a worse prognosis of COVID-19. This study aimed to determine the baseline vitamin D serum concentrations in asymptomatic or mildly symptomatic COVID-19 outpatients, as well as to evaluate the effects of supplementation with 10,00 IU/daily of vitamin D3 and its relationship with biochemical parameters and clinical features.
Interventions
DIETARY_SUPPLEMENTVitamin D3
Patients received oral supplementation of 10,000 IU daily for fourteen days of vitamin D3
Sponsors
University of Guadalajara
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Intervention group: Patients with positive PCR for COVID-19 of both sexes supplemented with vitamin D * Control group: Patients with positive PCR for COVID-19 of both sexes * Both groups: Mexican individuals, after signing the informed consent letter and over 18 years of age.
Exclusion criteria
• Diseases that compromise the absorption of Vitamin D; Crohn's disease, cystic fibrosis, and celiac disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Baseline levels of serum vitamin D in COVID-19 patients | At baseline | Evaluate serum levels of 25(OH)D (ng/mL) in patients with covid-19 from western Mexico |
| Correlation between D-dimer and vitamin D serum levels in COVID-19 patients | At baseline | Serum levels of D-dimer (ng/mL) will be measured at baseline and correlated with levels of 25(OH)D (ng/mL) in patients with covid-19 from western Mexico |
| Correlation between transferrin and vitamin D serum levels in COVID-19 patients | At baseline | Serum levels of transferrin (mg/dL) will be measured at baseline and correlated with levels of 25(OH)D (ng/mL) in patients with covid-19 from western Mexico |
| Correlation between ferritin and vitamin D serum levels in COVID-19 patients | At baseline | Serum levels of ferritin (ng/mL) will be measured at baseline and correlated with levels of 25(OH)D (ng/mL) in patients with covid-19 from western Mexico |
| Effects of vitamin D3 supplementation on COVID-19 patients | After 14 days of supplementation | Serum levels of 25(OH)D (ng/mL) will be determined in the intervention group after 14 days of Vitamin D3 supplementation |
Countries
Mexico
Outcome results
None listed