Sedentary Behavior
Conditions
Brief summary
We aim to analyze the impact of a single acute exercise intervention (ergometry) on the expression pattern of specific heart health related miRNAs in healthy, previously sedentary participants, and how this pattern will be changed after 4 months of increasing the weekly physical activity \>150 minutes.
Detailed description
Exercise induced changes in heat health related miRNA expression pattern are analyzed in plasma samples collected at rest and immediately after the completion of an all-out ergo spirometry test, conducted during the baseline examination. Additionally participants will perform a pulse wave analysis to evaluate their arterial stiffness, a bioimpedanzanalysis to evaluate their body composition, blood lipids will be measured as well as their exercise capacity. After the baseline examination, all participants will perform once per week a supervised endurance and strength training at our facility. In addition, the participants will be provided with a digital application for planning and documentation of their home based physical activity. Together with an expert, they plan their weekly physical activities so that they reach 150 min of physical activity each week over a period of 4 months. After this training/exercise intervention all participants will perform all measurements from the baseline examination again.
Interventions
Participates perform once a week for 4 months an in-house supervised endurance and strength training.
Participants are provided with an application for planning and documentation of their physical activity, together with an expert participants plan their physical activities for their home-based training to reach at least 150 min physical activity per week.
Sponsors
Ludwig Boltzmann Institute for Digital Health and Prevention
Paracelsus Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* \<150min physical activity per week * \>18 years of age * male and female * signed inform consents
Exclusion criteria
* acute or chronic cardiovascular diseases, exempt arterial hypertension (systolic blood pressure \>140 mmHg and diastolic blood pressure \>90 mmHg in untreated and medical treated subjects) * acute or chronic lung disease * Alcohol (\>30g/day) or drug abuse * Adipositas grad 2 (BMI \>35kg/m²) * Orthopedic limitations to exercise capacity * pregnant or breast feeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| miRNA expression response to acute all-out exercise (ergometry) | Baseline | expression change of miRNA due to all-out ergometry at baseline |
| Change from baseline miRNA expression at 4 months | after 4 months of exercise intervention | 4 months of exercise intervention in healthy previously sedentary participants leads to exercise-induced changes in the cardio protective miRNA expression profiles |
| Change from baseline in miRNA expression response to acute all-out exercise (ergometry) at 4 months | after 4 months of exercise intervention | 4 months of exercise intervention in healthy previously sedentary participants leads to a change in the acute exercise response (all-out ergometry). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| body composition | Before and after 4 months of exercise intervention | body composition will be measured before and after intervention |
| exercise capacity | Before and after 4 months of exercise intervention | exercise capacity will be measured by graded exercise testing on cycle ergometer. |
| Heart rate | Before and after 4 months of exercise intervention | Heart rate will be measured by graded exercise testing on cycle ergometer. |
| digital application | 4 months of exercise intervention | user feedback and user experience will be evaluated after the intervention |
| body weight | Before and after 4 months of exercise intervention | body weight will be measured before and after intervention |
| blood lipides | Before and after 4 months of exercise intervention | blood lipides will be measured before and after intervention |
| arterial stiffness | Before and after 4 months of exercise intervention | arterial stiffness will be measured before and after intervention |
Countries
Austria
Outcome results
None listed