Kidney Transplantation
Conditions
Keywords
Immunization Coverage, Transplant Recipient, Transplantation, Kidney, Infectious Disease Medicine
Brief summary
Solid-organ transplant patients are at increased risk of infectious diseases. Among this population, infectious diseases may be life-threatening or lead to graft rejection. Their prevention is an important challenge. Despite specific national recommendations, vaccination is underutilized. That is why we propose a dedicated infectious diseases consultation during pre-kidney transplantation assessment.
Detailed description
The main objective of this study is to impove vaccine coverage before kidney transplantation. Enrollment was based on the waiting list for a kidney transplant. Patients newly listed are invited to participate by the transplant team (nephrology department) ; for those that are already registered, a notification letter is sent to their home. All patients included must : * complete a health questionnaire * take a blood test at day 0 : viral, bacterial and parasitic serologies, QuantiFERON-TB * take a chest X-ray and dental panoramic Patients randomized in interventional group will be seen in specific infectious diseases consultation at Clermont Ferrand Hospital. A letter of recommendations is sent to nephrologist for patients randomized in group control. The primary study endpoint (immunization coverage) is evaluated at 6 months.
Interventions
OTHERSpecific infectious diseases consultation
Specific infectious diseases consultation at Clermont Ferrand Hospital with a specialist doctor : * Update vaccinations * Advice to travelers * Diagnostic and treatment of latent tuberculosis infection
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient over 18 * On the waiting list for kidney transplantation at Clermont-Ferrand * Free and informed consent * Affiliation to a social security system
Exclusion criteria
* Patient under 18 * Protected adults (individuals under guardianship by court order * Pregnant and nursing women * Prior graft (solid organs or hematopoietic stem cells) * Absence of consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vaccination coverage | Month 6 | The percentage of fully immunized patients according to the Recommendations of High Council for public Health |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Infectious complications | within the 6 months of the transplantation | Infectious diseases which require special management (hospitalization, anti-infective treatments) |
| Mortality | Month 6 | Mortality after kidney transplantation |
Countries
France
Contacts
Primary ContactLise LACLAUTRE
Outcome results
None listed