Three-dimensional Choroidal Vascularity Index in Common Fundus Diseases

Changes of Three-dimensional Choroidal Vascular Index by Optical Coherence Tomography in Common Fundus Diseases

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04790084

Enrollment

300

Registered

2021-03-10

Start date

2021-03-04

Completion date

2024-03-10

Last updated

2021-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Choroid

Keywords

choroidal vascularity index, fundus disease, choroidal blood flow

Brief summary

Explore the changes of choroidal blood perfusion in common fundus diseases by three-dimensional choroidal vascularity index, an optical coherence tomography (OCT) parameter.

Detailed description

Compared with the choroidal vascularity index on a single OCT image, the three-dimensional choroidal vascularity index can evaluate the choroidal changes of chorioretinal diseases as a whole. In this study, the choroidal changes of patients with common fundus diseases were systematically evaluated by collecting OCT and optical coherence tomography angiography (OCTA) images of patients with common fundus diseases, especially in healthy people, myopic people and patients with central serous chorioretinopathy.

Interventions

OTHERno intervention

no intervention

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

10 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

1. Healthy participants (1) Inclusion Criteria: 1) without systemic diseases such as diabetes and hypertension 2) best corrected visual acuity BCVA ≥ 1.0 3) aged 18 years or older (2)

Exclusion criteria

1) equivalent spherical refraction between -3 diopters and + 1.0 diopters 2) any visible lesions in the retina, optic nerve, or choroid 3) history of refractive or intraocular surgery 2. Myopia group (1) Inclusion Criteria: 1) equivalent spherical refraction greater than -0.25 diopters 2) without systemic diseases such as diabetes and hypertension 3) Best corrected visual acuity (BCVA) ≥ 1.0 4) aged 10 years or older (2)

Design outcomes

Primary

Measure	Time frame	Description
Three-dimensional choroidal vascularity index	baseline, pre-intervention	Three-dimensional choroidal vascularity index of healthy people and patients with common fundus diseases, based on optical coherence tomography.

Secondary

Measure	Time frame	Description
Choriocapillaris flow deficits%	baseline, pre-intervention	Choriocapillaris flow deficits% of healthy people and patients with common fundus diseases, based on optical coherence tomography angiography.

Countries

China

Contacts

Primary ContactCZ Chen, PHD

whuchenchzh@163.com13072765173

Backup ContactGP Sun, MD

sungongpeng@whu.edu.cn15827084278

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026