Major Depressive Disorder
Conditions
Keywords
stress, perceived control, neuroimaging, depression
Brief summary
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.
Detailed description
Participants in this research will include 40 female adolescents, aged 14-18, with Major Depressive Disorder (MDD) and 40 healthy adolescents from the greater Boston area by Dr. Emily Belleau, at McLean Hospital's Center for Depression, Anxiety and Stress Research. The study will include four sessions: * A clinical diagnostic interview as well as filling out a series of questionnaires and assessments. * The second session will include a functional magnetic resonance imaging (fMRI) brain scan to be conducted at the McLean Hospital Imaging Center. Participants will be asked to respond to surveys on their cell phone in the week following the fMRI brain scan. * The third session will include a diagnostic interview, assessments, and questionnaires to be completed three-months after the fMRI brain scan. Participants will be asked to complete surveys on their cell phone during the week following this three month follow-up session. * The fourth session will include a diagnostic interview, assessments, and questionnaires to be completed six-months after the fMRI brain scan. Participants will be asked to complete surveys on their cell phone during the week following this six month follow-up session.
Interventions
BEHAVIORALComputer Task Manipulation
Participants will complete computer tasks.
Sponsors
Mclean Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Case-Control Design
Eligibility
Sex/Gender
FEMALE
Age
14 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Inclusion Criteria: All Participants 1. Females of all ethnic origins See Section: Inclusion of Women and Minorities); 2. Ages 14-18 (See Section: Inclusion of Children); 3. Written informed assent/consent from adolescent and parent/guardian (if under age 18); 4. English as a first language or English fluency; 5. Right handed111; 6. Personal cell-phone (for Ecological Momentary Assessment \[EMA\]) 7 All participants will be in the follicular phase of their menstrual cycle when completing the functional magnetic resonance imaging (fMRI) study session Inclusion Criteria: MDD Sample 1. Meet Diagnostic Statistical Manual-5th edition (DSM-5) diagnostic criteria for major depressive disorder (as diagnosed with the KSADS) 2. Absence of any psychotropic medications for at least 2 weeks (6 weeks for fluoxetine; 6 months for neuroleptics; 2 weeks for benzodiazepines; 2 weeks for any other antidepressants); Inclusion Criteria: Healthy Control (HC) Sample 1. No history or current diagnosis of any DSM-5 psychiatric or substance/alcohol-related disorder (as diagnosed with the KSADS) 2. No first-degree relatives with a history of depression, bipolar disorder, or psychosis
Exclusion criteria
*
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood-Oxygen-Level-Dependent Imaging (BOLD) activation of the ventral striatum and ventral medial prefrontal cortex | 1.5 hour long scan during session 2 | BOLD activation of frontostriatal regions in response to computer tasks performed during the fMRI Brian scan |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cortisol Rating | collected as part of 1.5 hour long scan during session 2 | Saliva rating to be collected throughout the fMRI brain scan |
| Mood Rating | collected as part of 1.5 hour long scan during session 2 | Self-reported mood rating to be collected throughout the fMRI brain scan |
| Stress Reactivity Score | Longitudinal, three time points (baseline, 3-month follow-up, 6-month follow-up) | Stress Reactivity Survey Item collected via smart-phone delivered ecological momentary assessment |
| Stress Reactive Rumination Score | Longitudinal, three time points (baseline, 3-month follow-up, 6-month follow-up) | Stress Reactive Rumination Scale collected via smart-phone delivered ecological momentary assessment |
| Positive Affect Score | Longitudinal, three time points (baseline, 3-month follow-up, 6-month follow-up) | Positive Affect Survey Items collected via smart-phone delivered ecological momentary assessment |
Countries
United States
Contacts
CONTACTEmily L Belleau, PhD
PRINCIPAL_INVESTIGATOREmily L Belleau, PhD
Mclean Hospital
Outcome results
None listed