Aging, Healthy Aging
Conditions
Keywords
Cognition, Motor control, Vascular health
Brief summary
The primary objective of this study is to investigate the effects of strawberries on cognitive responses, motor control function, and vascular and cardiometabolic risk markers in healthy older adults.
Detailed description
To achieve the objectives, 40 healthy men and women ≥65 years of age will consume 26 g of freeze-dried strawberries in the form of a drink-mix daily for 8 wk. Using a randomized crossover study design, the effects will be compared to the effects of 8 wk intake of a placebo drink-mix (with a 4 wk wash-out period between trials). Cognitive function measurements will be performed at baseline and 8 wk. Additionally, at each timepoint, flow-mediated vasodilation and blood pressure will be measured followed by collection of fasting blood samples to assess glucose, insulin, blood lipids (free fatty acids, triacylglycerol, total cholesterol, LDL cholesterol, and HDL cholesterol), inflammatory markers (interleukins 6 and 18), and markers of oxidative stress (oxidized LDL-C and malondialdehyde).
Interventions
OTHERStrawberry
Freeze dried strawberry powder
OTHERPlacebo group
Comparative placebo powder
Sponsors
San Diego State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Intervention model description
Using a randomized crossover study design, the effects will be compared to the effects of 8 wk intake of a placebo drink-mix (with a 4 wk wash-out period between trials).
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy men and women 65 years and older
Exclusion criteria
* stroke or myocardial infarction * neurological disorders: * epilepsy, * multiple sclerosis, * Parkinson's disease, * stroke * known metabolic disorders: * liver, * renal * clinically diagnosed diabetes * drug treatment for lipid reduction or hypertension, * psychiatric medication use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in processing speed (cognition) at 8 weeks | At baseline, at 8 weeks | using Pattern Comparison Processing Speed Test |
| Change from baseline in executive function (cognition) at 8 weeks | At baseline, at 8 weeks | using Dimensional Change Card Sort Test; Flanker Inhibitory Control and Attention Test |
| Change from baseline in working memory (cognition) at 8 weeks | At baseline, at 8 weeks | using List Sorting Working Memory Test |
| Change from baseline in episodic memory (cognition) at 8 weeks | At baseline, at 8 weeks | using Picture Sequence Memory Test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in Vascular health at 8 weeks | At baseline, at 8 weeks | to better understand how changes in the gut microbiota through fruit consumption are linked to changes in health outcomes, we will assess endothelial function via flow-mediated vasodilation and risk factors for cardiometabolic dysfunction in fasting blood samples collected at baseline and after 8 weeks. |
Countries
United States
Outcome results
None listed