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Depression, Anxiety and Social Relationships as Risk Factors for Dementia

Depression as Risk Factor for Dementia

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04786561
Enrollment
11000
Registered
2021-03-08
Start date
2020-01-01
Completion date
2024-01-01
Last updated
2024-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety, Dementia, Dementia Alzheimers, Depression, Loneliness, Risk Factor, Social Isolation

Brief summary

The main objective of the present work is to establish a firm knowledge base regarding depression and anxiety as risk factors for dementia and how social relationships impact this association. This risk factors, and efforts to reduce them are described through a follow up over three decades.

Detailed description

The Health Study in Nord-Trondelag (HUNT) fulfils most of the key requirements of a population-representative cohort study by meeting the following elements: firm knowledge about the population denominator, knowledge about reasons for refusal (in line with previous methods in HUNT), options for levels and localisation of participation (at test station, at home, at nursing homes), coverage of sociodemographic features by the comprehensive HUNT4-protocol and register linkage, inclusion of institutionalized individuals and individuals with reduced capacity to consent, measurement of risk and compensatory factors across the life course by merging with previous results in HUNT surveys and linkage to registries, core elements and assessment methods can be compared with other European populations studies including elderly people, and finally, the ability to include biobank results in the data analysis. The HUNT data supplemented by register linkage include all established and suspected risk factors of dementia. A particular focus on primary health care is appropriate because it is in this part of the health care system that the need for extra resources due to the substantial increase in dementia prevalence is most pronounced. Furthermore, preventive measures in a life-course perspective will mainly have to be implemented in the primary health care setting.

Interventions

None listed

Sponsors

Norwegian Health Association
CollaboratorOTHER
Norwegian University of Science and Technology
CollaboratorOTHER
Norwegian Institute of Public Health
CollaboratorOTHER_GOV
University College, London
CollaboratorOTHER
Norwegian Centre for Ageing and Health
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Living in designated area

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frameDescription
Incidence of dementia diagnosis in HUNT4 70+ study2017-2019Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.
Incidence of Minimal Cognitive Impairment (MCI) in the HUNT 70+ study2017-2019Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.

Secondary

MeasureTime frameDescription
Change in loneliness1995-2019Self-reported feeling of loneliness

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026