Macula Lutea Opacity
Conditions
Keywords
lutein, absorption, supplement
Brief summary
The aim of this study is to investigate in healthy adults, 18-40 years of age, how the absorption of 5 mg of L differs between consumption as a supplement, blended foods, and whole food equivalent of blended foods.
Detailed description
The absorption the macular carotenoids has shown variability between different supplements, and food sources such as egg and spinach. Investigation of the absorption of different forms of food (e.g. cooked, raw, blended) is not as well studied. Investigating the absorption of lutein from different forms of food is important to be able to prescribe lutein from forms of food that will be optimally absorbed.
Interventions
DIETARY_SUPPLEMENTLutein supplement
5 mg lutein supplement.
OTHERFood, blended
5 mg lutein from baby spinach, blended.
OTHERFood, unprocessed
5 mg lutein from baby spinach, in whole food form.
Sponsors
The University of Queensland
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and females 18 to 40 years. * Generally healthy. * No participant reported history of clinically significant medical conditions including, but not limited to, cardiovascular, neurological, psychiatric, renal, immunological, endocrine (including uncontrolled diabetes or thyroid disease) or haematological abnormalities that are uncontrolled. * Non-smoker. * English language proficiency
Exclusion criteria
* Participant reported diagnosis of serious ocular conditions (e.g. cataracts, glaucoma, diabetic retinopathy, retinitis pigmentosa, Stagardt's disease) * Participant reported diagnosis, or current treatment of age-related macular degeneration. * Participant reported diagnosis of epilepsy. * Participant aversion, intolerance or allergy to study foods to be consumed (spinach, ginger, lemon, apple, flaxseeds) * A female currently pregnant or trying to fall pregnant. * Current or past smoker (within last 12 months). * Under 18 or over 40 years of age. * Currently taking a lutein supplement or consuming large amounts of foods containing lutein on a regular basis (\>3 days per week).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma lutein concentration | Study visit 1 (24 hours), Study visit 2 (24 hours), study visit 3 (24 hours) | Area under the curve of plasma lutein concentrations between 0 and 24 hours post lutein consumption. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma lutein maximum concentration | Study visit 1 (24 hours), Study visit 2 (24 hours), study visit 3 (24 hours) | Maximum concentration of plasma lutein reached over 24 hours of measurement, and time point of maximum concentration. |
| Macular pigment optical density | Study visit day 1, day 8, day 15 | Machine: measured by the Macular Pigment Screener II (Elektron Eye Technology). The non-invasive test uses heterochromatic flicker photometry. One measure completed at each study visit (3 study visits total). |
| Daily dietary lutein and zeaxanthin intake | Study visit day 1 | Daily dietary intake of lutein and zeaxanthin (mg/day) as measured by a food frequency questionnaire. |
Countries
Australia
Outcome results
None listed