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Natural History and Patient Journey in Atrial Fibrillation: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

Natural History and Patient Journey in Atrial Fibrillation: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04786366
Enrollment
5601803
Registered
2021-03-08
Start date
1998-01-01
Completion date
2021-06-30
Last updated
2021-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Epidemiology

Keywords

Atrial Fibrillation, healthcare contacts, Electronic Health Records, epidemiology, comorbidity, health inequality

Brief summary

The trajectory of atrial fibrillation (AF) patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the AF incidence, mortality and case-fatality, the investigators implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident AF.

Interventions

OTHERThe study does not have an intervention, but observe the AF incidence of the UK disease-free population

The study does not have an intervention, but observe the AF incidence of the UK disease-free population.

Sponsors

University College, London
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum

Inclusion criteria

* The investigators identify individuals aged 18 years or older and registered in the current primary care practice for at least one year.

Exclusion criteria

* Individuals are excluded if they had a prior history of AF before study entry.

Design outcomes

Primary

MeasureTime frameDescription
Incidence of Atrial fibrillationJan 1st 1998 - May 31st 2016AF incidence in the population
Mortality of Atrial fibrillationJan 1st 1998 - May 31st 2016Mortality among AF patients

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 8, 2026