Periodontal Regeneration
Conditions
Keywords
Chronic periodontitis, Intra-bony defects, Minimally invasive surgical technique, Platelet rich fibrin,, Growth factor enhanced matrix 21S
Brief summary
Twenty-one intra-bony defects in fifteen systemically healthy patients with moderate to severe chronic periodontitis were randomly classified into 3 groups, 7 sites each. Group І treated by MIST alone, group ІІ treated by MIST + ethylenediamine-tetraaceticacid (EDTA) + PRF and group III treated by MIST + EDTA + GEM 21S. The clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL) and bleeding on probing (BOP), were recorded at baseline, 3, 6 and 9 months post-surgery. Cone beam computed tomography (CBCT) was performed at baseline and 9 months post-surgery to evaluate bone level and bone density
Detailed description
: Twenty-one intra-bony defects in fifteen systemically healthy patients with moderate to severe chronic periodontitis were randomly classified into 3 groups, 7 sites each. Group І treated by MIST alone, group ІІ treated by MIST + ethylenediamine-tetraaceticacid (EDTA) + PRF and group III treated by MIST + EDTA + GEM 21S. The clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL) and bleeding on probing (BOP), were recorded at baseline, 3, 6 and 9 months post-surgery. Cone beam computed tomography (CBCT) was performed at baseline and 9 months post-surgery to evaluate bone level and bone density.
Interventions
PROCEDUREMinimal invasive flap technique
contained defect treated with Minimally invasive flap
PROCEDUREMinimally invasive flap with root conditioning (EDTA) and platelet rich fibrin
contained defect treated by Minimally invasive flap with root conditioning (EDTA) and platelet rich fibrin graft
COMBINATION_PRODUCTminimally invasive flap with root contioning by EDTA and growth factor enhanced matrix GEM21S
contained defect treated with Minimally invasive flap with root conditioning (EDTA) and growth factor enhanced matrix application in the defect
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
30 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
• Presence of at least one tooth with PPD and CAL loss of ≥ 5 mm associated with an intra-bony defect of ≥ 2 mm according to Cortellini and Tonetti, 2007
Exclusion criteria
* Patients with uncontrolled or poorly controlled diabetes, life-threatening conditions, or requiring antibiotic prophylaxis were excluded. * Smokers * Pregnant patients. * Patients with aggressive periodontitis. * Patients with multiple interconnected vertical defect walls.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the change in probing pocket depth | 9 months | the change in probing pocket depth was measured at baseline, 3,6 and 9 months evaluation period using periodontal probe |
| the change bleeding on probing score | 9 months | the change in bleeding on probing measured at baseline,3,6 and 9 months evaluation period |
| the change Clinical attachment level | 9 months | the change in Clinical attachment level measured at baseline, 3,6 and 9 months using the periodontal probe |
| Cone beam radiograph | 9 months | Cone beam radiograph for measuring the change in area of the defect, depth of the depth and bone density at baseline, 3, 6 and 9 month post operative treatment using OnDemand software of cone beam |
Countries
Egypt
Outcome results
None listed