Copd, Emphysema, Hyperinflation
Conditions
Brief summary
This study will investigate the utility of 4D Medical's X-ray Velocimetry (XV) imaging analysis software for the detection of hyperinflation, and compare endobronchial valve placement outcomes with predictive indices obtained utilizing this technique.
Interventions
DIAGNOSTIC_TEST4D X-ray Velocimetry
X-ray velocimetry uses fluoroscopy to quantify local ventilation in the lung.
Sponsors
American Thoracic Society
Vanderbilt University Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Inclusion: * CT chest and PFTs within the last two years * Age over 18 * COPD with emphysema * Global Initiative for Chronic Obstructive Lung Disease (GOLD) 3 - 4 classification OR modified Medical Research Council (mMRC) score of 2 or greater.
Exclusion criteria
* Pregnancy * Presence of an additional pulmonary disease beyond COPD * Inability to raise arms above 90 degrees as required for fluoroscopy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ratio of residual volume over functional residual capacity by 4DXV | 6 months | We will compare an XV hyperinflation index to traditional pulmonary function tests (PFTs) and outcomes |
| Expiratory Time Constants vs Fissure Completeness | 1 year | We will examine the correlation between lobar expiratory time constants and fissure completeness by StratX |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in Saint George Respiratory Questionnaire (SGRQ) | 1 year | We will compare SGRQs pre and post valve placement to hyperinflative indices by 4D XV |
Countries
United States
Outcome results
None listed