Long-term Prognosis of Emergency Aneurysmal Subarachnoid Hemorrhage

Conditions

Aneurysmal Subarachnoid Hemorrhage

Brief summary

Rupture of intracranial aneurysms can lead to extensive subarachnoid hemorrhage (SAH), a potentially fatal neurological emergency with mortality rates ranging from 8 to 67%. At present, surgical clipping (SC) and endovascular coiling (EC) are two main treatments for aneurysmal subarachnoid hemorrhage (aSAH), in recent years, the improvements in surgical equipment and techniques have already greatly improved the postoperative safety of patients. However, considering individual differences between patients, some still at risk due to possible complications during hospitalization or after discharge from the hospital, it will no doubt generate a large healthcare burden. This prospective, observational clinical trial (LongTEAM) is to improve the diagnosis and treatment effect and efficiency in this field, reducing mortality, medical costs, and medical burden, while opening up new avenues for interdisciplinary clinical practice and scientific research exploration.

Tang X, Wang X, Zhu B, Zhou L, Chen X.

2026-01-12

10.3389/fneur.2025.1648805

Low-Field Portable MRI Detects Developmental Pattern of Ultraearly Cerebral Infarction in aSAH.

Yu T, Lau TY, Liu Y, Li R, Lin F, Song Z, Zhu Q, Chen Y, Li T, Jing J, Chen X.

2025-12-111 citations

10.1161/strokeaha.125.052474

Increased triglyceride-glucose index is associated with adverse functional outcome for patients with aneurysmal subarachnoid hemorrhage after surgical clipping and endovascular coiling: insights from a large cohort study

Xielin Tang, Bingcheng Zhu, Minghao Liu, Fa Lin, Runting Li et al. (9 authors)

Frontiers in Neurology2025-09-10

10.3389/fneur.2025.1622819

Association between geriatric nutritional risk index and clinical outcome of elderly aneurysmal subarachnoid hemorrhage patients: insights from a large cohort study.

Yang Y, Zhu B, Lin F, Li R, Chen X.

2025-02-04

10.1007/s10143-025-03209-6

The effect of sex differences on complications and 90-day outcomes after aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis.

Li R, Lin F, Chen Y, Lu J, Yang J, Han H, Yuan K, Wang K, Yan D, Li R, He S, Li Z, Zhang H, Chen X, Ma L, Zhao Y, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Li Y, Wang S, Chen X, Zhao Y.

2022-07-234 citations

10.1007/s10143-022-01836-x

A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score.

Li R, Lin F, Chen Y, Lu J, Han H, Ma L, Zhao Y, Yan D, Li R, Yang J, He S, Li Z, Zhang H, Yuan K, Wang K, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Zhao Y, Zhang Y, Li Y, Wang S, Chen X, Zhao Y.

2022-05-1418 citations

10.1007/s12975-022-01033-4

Elevated blood hemoglobin on admission as an independent predictor of unfavorable outcomes in patients with aneurysmal subarachnoid hemorrhage.

Li R, Lin F, Chen Y, Lu J, Han H, Ma L, Zhao Y, Yan D, Li R, Yang J, He S, Li Z, Zhang H, Yuan K, Wang K, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Zhao Y, Zhang Y, Li Y, Wang S, Chen X, Zhao Y.

2022-04-025 citations

10.1007/s10143-022-01780-w

Application of Intracranial Pressure-Directed Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

Jun Yang, Junlin Lu, Runting Li, Fa Lin, Yú Chen et al. (18 authors)

Frontiers in Aging Neuroscience2022-03-148 citations

10.3389/fnagi.2022.831994

Prognostic Value of Elevated Cardiac Troponin I After Aneurysmal Subarachnoid Hemorrhage

Fa Lin, Yú Chen, Qiheng He, Chaofan Zeng, Qingzhen Zhang et al. (9 authors)

Frontiers in Neurology2021-05-3114 citations

10.3389/fneur.2021.677961

Interventions

PROCEDURESurgical clipping and endovascular coiling

Surgical clipping: Apply aneurysm clip to clip the ruptured aneurysm. Endovascular coiling：Also called endovascular embolization, to block blood flow into an aneurysm.Preventing blood flow into an aneurysm helps to keep it from rupturing.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

No

Inclusion criteria

* All patients admitted to the emergency department of the investigator with aneurysmal subarachnoid hemorrhage are included in their prospective registry.

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
Unfavorable neurological outcome (mRS>2)	10 days after the procedure	Number of patients experiencing a unfavorable neurological outcome at discharge, defined as a modified Rankin Scale (mRS) score of \>2.

Secondary

Measure	Time frame	Description
Cognitive deficits	10 days after the procedure	Number of patients experiencing a unfavorable neurological outcome at discharge,defined as changes in thinking, emotion, will and behavior.
Major adverse cardiac or cerebrovascular events	10 days after the procedure	Number of patients experiencing an event including all-cause death, non-fatal cerebrovascular event, non-fatal any myocardial infarction and revascularization at discharge.

Countries

China

Contacts

Primary ContactRunting Li, MD

1011168227@qq.com+8615753166690

Backup ContactXiaolin Chen, MD

xiaolinchen488@hotmail.com+8613810624845

Outcome results

None listed