PRF Pulpotomy Using Different Bioceramic Materials in Permanent Molars

Outcome of PRF Pulpotomy Using Different Bioceramic Materials in Permanent Molars With Irreversible Pulpitis: A Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04784949

Enrollment

120

Registered

2021-03-05

Start date

2019-08-01

Completion date

2021-01-01

Last updated

2021-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible Pulpitis

Keywords

PRF, Vital pulp therapy, pulpotomy, bioceramics

Brief summary

this study aimed to compare the clinical and radiographic outcomes of full pulpotmy after application of Biodentine, or MTA, or Portland cement above PRF membrane In permanent molars with irreversible pulpitis

Interventions

PROCEDUREportland cement

pulpotomy with PRF and white Portland cement

PROCEDUREMineral trioxide aggregate

pulpotomy with PRF and white Mineral trioxide aggregate

PROCEDUREBiodentine

pulpotomy with PRF and Biodentine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Intervention model description

permanent molar with symptomatic irreversible pulpitis

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* spontaneous, lingering pain exacerbated by hot and cold , and/or radiating pain * Responded to cold and electric pulp testing

Exclusion criteria

* pain on palpation, percussion, * mobility or swelling * peridontall widening * Teeth with marginal periodontitis or crestal bone loss * resorption * calcified canals

Design outcomes

Primary

Measure	Time frame	Description
Change in postoperative pain	24 hours, 48 hours, 1 week, every 3 months for 12 months	persistence , relief , or exacerbation of pain using visual analogue scale for pain score
Change in swelling	24 hours, 48 hours, 1 week, every 3 months for 12 months	appearance of periapical swelling or facial swelling after the clinical procedures (Binary outcome: Yes/No)
Change in Mobility	24 hours, 48 hours, 1 week, every 3 months for 12 months	appearance of teeth mobility after the clinical procedures (record of periodontal pocket depth)

Secondary

Measure	Time frame	Description
calcific like bridge	12 month	measure of the calcific bridge thickness using CBCT

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026