Coronary Artery Disease
Conditions
Brief summary
OBJECTIVES The goal of this study is to evaluate the self-achieved smoking cessation supported with cytisine smoking cessation and its' on platelet aggregation and prothrombotic state in patients after coronary angiography and PCI. BACKGROUND Cigarette smoking is a major risk factor of coronary artery disease (CAD). Smoking cessation is one of the most cost-effective intervention in lifestyle. Self-reported rates of smoking cessation are reasonably low. Cytisine is promising drug in support of smoking cessation. Smoking affects various components leading to arterial thrombosis, and the effect of smoking cessation on prothrombotic state and platelet aggregation is still under investigation GOAL To assess rates of smoking cessation in patients after coronary angiography and PCI and factors influencing success in smoking cessation To assess feasibility, safety and efficacy of cytisine in smoking patients To assess effect of smoking cessation on platelet aggregation in patients treated with clopidogrel and on prothrombotic state. METHODS A prospective nonrandomized observational study of patients after coronary angiography.
Interventions
None listed
Sponsors
Centre of Postgraduate Medical Education
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients after coronary angiography or PCI, * Aged 18 years or older, * Smoking at least 10 cigarettes a day
Exclusion criteria
• Pregnancy Criteria may vary in substudies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelet aggregation in patient treated with clopidogrel after smoking cessation | 30-days | Platelet reactivity measured with PRU |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prothrombotic state | 30-days | Various biomarkers |
| Cotinine | 30-days | Changes in concentration of cotinine |
| Thrombin potential | 30-day | Assessment of endogenous thrombin potential |
| Thrombomodulin | 30-days | Changes of thrombomodulin concentration |
| PF-4 | 30-days | Changes of PF-4 concentration |
| Thromboglobulin | 30-days | Changes of thromboglobulin concentration |
| PAI-1 | 30-days | Changes of PAI-1 concentration |
| P-selectin | 30-days | Changes of p-selectin concentration |
Other
| Measure | Time frame | Description |
|---|---|---|
| Smoking cessation | 30-days, 6-months, 12-months | Factors influencing smoking cessation. Smoking cessation assessed with NicAlert test and self-reported |
| Cytisine as smoking cessation aid | 30-days | Feasibility,safety and effectiveness of cytisine. Number of patients with confirmed smoking cessation.Number of adverse events |
Outcome results
None listed