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Evaluation of the Intra-observer Agreement of the HEP Score in Surgical Intensive Care.

Evaluation of the Intra-observer Agreement of the HEP Score in Surgical Intensive Care.

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04782843
Acronym
REPROHEP
Enrollment
124
Registered
2021-03-04
Start date
2021-03-01
Completion date
2021-05-01
Last updated
2021-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heparin-induced Thrombocytopenia

Keywords

Heparin-induced Thrombocytopenia, HEP score

Brief summary

The main objective of this work is to assess the intraoperator reproducibility in the calculation of the HEP score in a population of intensive care patients.

Detailed description

The HEP score (HIT Expert Probability) is also a clinical probability score, created thanks to the experience of clinicians (16). It is very recent and therefore still little studied and little used. In particular, it has not been the subject of a prospective validation study for ICU patients. The use of this score is therefore not recommended in everyday practice. However, the literature shows a higher diagnostic value of the HEP score especially for resuscitation-type patients, as well as when used by an operator with little experience. This could be due to greater detail given in consideration of other causes of thrombocytopenia (17). The main objective of this work is to assess the intraoperator reproducibility in the calculation of the HEP score in a population of intensive care patients. The secondary objectives will aim to: * Evaluate inter-operator reproducibility * Determine if the reproducibility of the HEP score is influenced by: The patient's sex The type of heparin used (LMWH vs UFH) The severity of the patient (IGS2 score) A history of cardiac or orthopedic surgery The expected consistent benefits allow validation of the HEP score in surgical intensive care (cf. EVHEP-TIH study). This would allow a better assessment of the pre-test probabilities of TIH with the performance of biological tests.

Interventions

OTHERHEP score assessement

Assessement of the HEP score between 2 physician.

Sponsors

Centre Hospitalier Universitaire de Besancon
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* any adult patient (age ≥ 18 years), admitted to surgical intensive care, treated with heparin (UFH or LMWH), and suspected of TIH by a clinician in the department according to the criteria of the SFAR 2002.

Exclusion criteria

* Non-inclusion criteria: minor patients, pregnant women and adults incapable

Design outcomes

Primary

MeasureTime frameDescription
Intraobserver agreeement for the HEP score3 monthsIntraobserver agreeement for the HEP score

Secondary

MeasureTime frameDescription
Interobserver agreement for the HEP score3 monthsInterobserver agreement for the HEP score

Contacts

Primary ContactRudy Alardin, Intern
ralardin@chu-besancon.fr0621605385

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026