EBV Infection
Conditions
Brief summary
This study is a single-center, prospective, observational clinical study to evaluate the Application of saliva EBV-DNA Detection in EBV Infection Related Diseases
Interventions
DIAGNOSTIC_TESTSaliva Testing
Saliva EBV-DNA Detection comparing with PBMC and plasma EBV-DNA
Sponsors
Beijing Friendship Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. According to the HLH-04 diagnostic criteria, it meets the HLH diagnostic criteria. EBV infection occurs in cells with EBV-DNA copy number significantly increased in peripheral blood or tissue, or where EBV coding small RNA(EBER) is detected in tissue or peripheral blood. Or Straus' 1988 diagnostic criteria for CAEBV. 2. Informed consent
Exclusion criteria
1. Patients who cannot cooperate with saliva collection 2. Patients who are unwilling to cooperate with the project research according to the project research plan.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnosis | baseline | The sensitivity and specificity of saliva EBV-DNA detection level as a diagnosis for EBV infection-related diseases, and whether it can replace peripheral blood EBV-DNA monitoring |
| Monitoring | 2 to 12 weeks after treatment | The sensitivity and specificity of saliva EBV-DNA detection level as a monitoring method for EBV infection-related diseases, and whether it can replace peripheral blood EBV-DNA monitoring |
Countries
China
Contacts
Primary ContactZhao Wang, Dr
Outcome results
None listed