Respiratory Amplitude, Portal Blood Flow, MRI, Echo Planar Imaging
Conditions
Keywords
Respiratory amplitude, Portal Blood Flow, MRI, Echo Planar Imaging
Brief summary
The analysis of portal vein blood flow is important when assessing the severity and progression of liver disease. It is important to understand normal liver regulation in order to appreciate the evaluation of the effect of treatment during the disease progression. The influence of respiration on hepatic hemodynamics is still poorly understood, although some studies have shown a significant impact. The purpose of this project is to quantify the blood flow variations in the portal vein at different positions during the respiratory cycle by using a fast MRI sequence and an Echo Planar (EPI) acquisition.
Interventions
OTHERperipheral ECG
Subjects will be placed in supine position. The systematic use of a headset will reduce the noise inherent to the machine. A cardiac synchronization system using peripheral ECG allows the synchronization with the subject's heart rate.
OTHERStandard MRI
Standard MRI examination using a torso coil consists of morphological and phase-contrast flow sequences(standard and EPI acquisitions).
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 18 ans * Healthy subject without history of hepatic disease
Exclusion criteria
* history of hepatic pathology * pregnant woman * claustrophobia * major obesity * any contraindication to MRI exam
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| flow rates variation between the fast sequence averaged values and the standard sequence | 30 minutes | flow rates variation between the fast sequence averaged values and the standard sequence during free breathing. |
Countries
France
Outcome results
None listed