DNA Damage, Radiation Induced, Oxidative Stress, Radiation Exposure
Conditions
Brief summary
Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells. While the amount of DNA damage that may occur from one scan is not harmful to your overall health, there could be concerning damage in patients who are constantly exposed to this radiation. Currently, there is no way to prevent DNA damage during a medical scan. One potential way to fight the oxidative stress caused by radiation is to take an antioxidant before a scan. The purpose of this study is to see if a combination of antioxidants can protect someone from the damage that radiation causes to the DNA of their white blood cells.
Interventions
Multi-nutrient supplement containing a combination of vitamins, minerals and antioxidants
DRUGPlacebo
Placebo
Sponsors
McMaster University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 74 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 to 76 years. * Scheduled for bone scan procedure at the Juravinski Hospital.
Exclusion criteria
* History of smoking within six months prior to study enrollment. * Known hypersensitivity reactions to any of the ingredients in the MNSRP. * Chemotherapy or radiation therapy within six months prior or one month following study enrollment. * Individuals currently taking vitamin or mineral supplements that contain antioxidants will be considered on a case-by-case basis but will be asked to refrain from intake for at least two weeks prior to partaking in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of gamma-H2Ax foci per PBMC nucleus | Three hours following radiation exposure | Number of gamma-H2Ax foci per PBMC nucleus three hours following radiation exposure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Amount of amplifiable mtDNA in PBMC's | Three hours following radiation exposure | Amount of amplifiable mtDNA in PBMC's three hours following radiation exposure |
| Abundance of mtDNA deletions in PBMC's | Three hours following radiation exposure | Abundance of mtDNA deletions in PBMC's three hours following radiation exposure |
| Abundance of phosphorus-ATM in PBMC's | Three hours following radiation exposure | Abundance of phosphorus-ATM in PMBC's three hours following radiation exposure |
Outcome results
None listed