The Effect of Early Switching From Intravenous to Oral Antibiotics Therapy

The Effect of Early Switching From Intravenous to Oral Antibiotics Therapy: a Randomized Control Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04781439

Enrollment

210

Registered

2021-03-04

Start date

2020-03-01

Completion date

2020-09-29

Last updated

2021-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin and Subcutaneous Tissue Infection

Keywords

effectiveness, antibiotics

Brief summary

To date, many studies showed the great benefits of switching from IV to PO antibiotics in some infectious diseases, especially skin and soft tissue, urinary tract, respiratory tract, gallbladder, and biliary tract infection. Higher level of evidence is necessary to confirm the benefit of early switching protocol in infectious condition management. Therefore, we conducted a clinical trial to investigate the effectiveness and cost of IV-to-PO antibiotic switch therapy in some surgical infection conditions.

Detailed description

Introduction: The benefit of early switching from intravenous (IV) to oral (PO)was raising from the last decade. This randomized clinical trial was to evaluate the effect of early switching from IV to PO antibiotics on the outcome of surgical patients at a public hospital. Methods: Patients admitted for a therapeutic antibiotic to orthopedic and general surgery conditions were randomly assigned to three groups: control (non-switching), early switching (within 48-72 hours), and late switching (after 72 hours). The rate of effectiveness of each arm, length of hospital stay, length of IV antibiotics, and cost were recorded prospectively.

Interventions

PROCEDUREIV-to-PO conversion of antibiotics

IV-to-PO switching of antibiotics treatment

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* on the second day of IV antibiotic * no difficulties on taking oral medication * clinical improvement

Exclusion criteria

* n/a

Design outcomes

Primary

Measure	Time frame	Description
rate of effectiveness	3 months	rate of effectiveness of the infection treatment

Secondary

Measure	Time frame	Description
length of hospital stay	3 months	length of hospital stay after starting the antibiotic treatment
length of IV antibiotics	3 months	length of IV antibiotics usage
cost of treatment	3 months	cost of antibiotics

Countries

Vietnam

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026