Gut Tumor, Neuroendocrine Tumors, Surgery
Conditions
Brief summary
To evaluate two competitive strategies in patients undergoing resection of Small-intestine Neuroendocrine neoplasms (Si-NEN): Prophylactic Cholecystectomy (PC) versus On-demand delayed cholecystectomy
Detailed description
This is a retrospective study based on 230 Si-NENs candidates to the primary tumor resection. Patients were divided into two arms: PC and OC. Propensity score matching was performed, reporting the d value. The primary outcome was the re-hospitalization rate for any cause. The secondary endpoints were the re-hospitalization rate for biliary stone disease (BSD), the mean number of re-hospitalization (any cause and BSD), the complication rate (all and severe), and the total costs. A P-value \< 0.05 was considered significant, and NNT\< 10 was considered clinically relevant.
Interventions
PROCEDURECholecystectomy
Laparoscopic or laparotomic cholecystectomy
Sponsors
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with a diagnosis of Si-NEN; * resection of the primary tumor with or without concomitant cholecystectomy; * absence of a history of a biliary stone disease or cholecystectomy before Si-NEN diagnosis
Exclusion criteria
\- presence of a history of a biliary stone disease or cholecystectomy before Si-NEN diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| re-hospitalization rate for any cause | through study completion, an average of 7 years | the re-hospitalization rate for any cause after primary tumor surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| re-hospitalization rate for biliary stone disease | through study completion, an average of 7 years | the re-hospitalization rate for biliary stone disease after primary tumor surgery |
| mean number of re-hospitalization any cause | through study completion, an average of 7 years | the mean number of re-hospitalization for any cause after primary tumor surgery |
| mean number of re-hospitalization biliary stone disease | through study completion, an average of 7 years | the mean number of re-hospitalization for biliary stone disease after primary tumor surgery |
| total costs | through study completion, an average of 7 years | total costs for primary tumor surgery plus any re-hospitalization |
| COmplication rate | through study completion, an average of 7 years | COmplication rate after primary tumor resection |
Outcome results
None listed