Omega-3 Supplementation Combined With Endurance Training Improve Running Economy in Recreational Runners.

12 Weeks of Omega-3 Supplementation Combined With Endurance Training Improve Running Economy in Recreational Runners. The Potential Role of the Myokines-NO Pathway.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04780451

Enrollment

Registered

2021-03-03

Start date

2020-09-16

Completion date

2021-03-02

Last updated

2021-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of Omega-3 Supplementation on Exercise Performance and Muscle Tissue Functions

Keywords

omega-3, supplementation, endurance training, running

Brief summary

Recreational male runners participated in 12 weeks training and omega-3 supplementation programme. Before starting and at the end of the 12-week cycle, the runners performed an increasing intensity treadmill test where oxygen uptake and VO2 peak were assessed.

Detailed description

40 healthy, recreational male runners participated in 12 weeks training and supplementation programme. The training protocol was built based on undulatory load manipulation 3:1, which was suggested to be effective to prevent overtraining and stress due to oscillations between volume/intensity. Throughout the study all participants took 4 identical-looking capsules per day (2 in the morning and 2 in the evening) containing either omega-3 fatty acids or medium chain triglycerides as placebo in total amount of 4g of fat per day. Before starting and at the end of the 12-week cycle, the runners performed an increasing intensity treadmill test where oxygen uptake and VO2 peak were assessed. Additionally, blood was collected to determine the concentrations of selected proteins (including eNOS, irisin, adiponectin) that may be associated with potential changes in participants' oxygen uptake during the treadmill test.

Interventions

DIETARY_SUPPLEMENTOmega-3 supplementation in recreational runners

Male recreational runners participated in 12 weeks of endurance training combined with omega-3 fatty acids supplementation. Before starting and at the end of the 12-week cycle, the runners performed an increasing intensity treadmill test where oxygen uptake and VO2 peak were assessed.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

MALE

Age

29 Years to 42 Years

Healthy volunteers

Yes

Inclusion criteria

* non smoking * no chronic diseases * no supplements and medicines * personal best in 10km run between 35 and 59 min at the turn of 2016 and 2020 y

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
changes in oxygen consumption during running test	between 10 and 25 minutes of the running test

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026