Cyanoacrylate Tissue Adhesives Versus Silk Suture at the Palatal Donor Site of Sub Epithelial Connective Tissue Graft

Evaluation of Post Operative Pain, Early Wound Healing, and the Time of Application of Cyanoacrylates Tissue Adhesives Versus Silk Sutures at the Palatal Donor Area of Subepithelial Connective Tissue Grafts (CTG) A Randomized Clinical Trial: Comparative Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04780360

Enrollment

Registered

2021-03-03

Start date

2021-02-01

Completion date

2021-12-01

Last updated

2021-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Effect of Local Aplication of Cayanoacrylate Tissue Adhesives on Improving the Healing

Brief summary

Subepithelial connective tissue grafts (CTG) are considered the gold standard procedure with proven clinical success when it comes to gingival augmentation aims to to improve periodontal health, which can enhance the long-term prognosis of teeth by obtaining soft tissue coverage of exposed root surfaces and/or augmentation the dimensions of gingival tissue. The procedure require harvesting tissue from a the palate, which increases the complexity of the procedure and patient discomfort. Complications after harvesting a graft would be pain, inflammation, bleeding, flap necrosis and infection in the donor site.

Interventions

PROCEDURECayanoacrylate tissue adhesives

Cyanoacrylates are a family of strong fast-acting adhesives with industrial, medical, and household uses. They are various esters of cyanoacrylic acid. The acryl groups in the resin rapidly polymerize in the presence of water to form long, strong chains

PROCEDURESilk suture

Non Absorbalble suture materiel used to fixed the edges of the incision in place until healing

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with mucogingival defects scheduled for sub epithelial connective tissue graft * Age at least 18 years. * Not having any systemic disease that could compromise wound healing * No periodontal surgery on the experimental sites. * No smoking, * No pregnancy or lactation

Exclusion criteria

* Patients with coagulation disorders * patients on corticosteroids, with uncontrolled diabetes, or with any systemic disease that precluded periodontal surgery * patients with a history of contact dermatitis to formaldehyde * Loss of maxillary premolars and molars * Medications or antibiotics used in the previous 6 months * Pregnancy or lactation * Smoking

Design outcomes

Primary

Measure	Time frame	Description
Early Wound Healing	1 week	Measured By Modified Early Wound Healing Index

Countries

Egypt

Contacts

Primary ContactMohamed S Mohamed Ibrahium Abdullah, Invistegator

dr.mohamed15.ms@gmail.com01283626196

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026