Ultra-endurance Athletes With Gastrointestinal Symptoms
Conditions
Keywords
signs and symptoms, digestive, Probiotics, Oral rehydration therapy, Gastrointestinal Microbiome
Brief summary
Ultra-endurance athletes have been commonly endured extreme conditions during races and training sessions, resulting in exercise-associated clinical symptoms, including gastrointestinal symptoms, dehydration, and elevated oxidative stress. Although these alterations adversely affect sports performance and well-being, there is no certain treatment or consensus on alleviating the exercise-associated clinical symptoms in ultra-endurance athletes. The objective of this study is to determine the effects of oral rehydration salts supplemented with Lactobacillus Rhamnosus GG on exercise-induced gastrointestinal problems, dehydration and oxidative stress in ultra-endurance athletes. Additionally, we aimed to assess the exercise-induced alterations in oxidative stress determined by applying an acute strenuous exercise protocol ((a cycle ergometer (45 min at 65%VO2max) immediately followed by a treadmill test (75% VO2max to exhaustion)) before and after the supplementation period.
Interventions
DIETARY_SUPPLEMENTOral Rehydration Salts supplemented with L. Rhamnosus GG
A supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, Lactobacillus Rhamnosus GG ATC53103 HN019 strain and fructooligosaccharides
DIETARY_SUPPLEMENTOral Rehydration Salts only
A supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, microcrystalline cellulose
Sponsors
Istanbul Medeniyet University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Ultra-endurance athletes with at least one gastrointestinal symptoms will be administered oral rehydration salts supplemented with L. Rhamnosus GG or oral rehydration salts only for 4 weeks
Eligibility
Sex/Gender
ALL
Age
20 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
* Participants who train at least 15 h per week, * Participants who do not have any metabolic disease, * Have had at least one gastrointestinal symptom determined by using a Gastrointestinal Symptoms Rating Scale and Bristol Stool Chart Form Scale, * Being a non-smoker, * Have participated in at least one ultra-endurance race/event (lasts \> 4 hr), * Taking no vitamins, minerals, dietary supplements, antibiotics, and any medication at least during the three months before the study, * (For women) participants with a regular menstrual cycle of physiological length (24-35 days)
Exclusion criteria
* Regular tobacco use * Inability to adhere to any of the study protocol requirements (i.e. alcohol, caffeine consumption, diet control) * Having consumed any supplements and/or medicines for the preceding 3 months period. * (For women) participants in menopause or using oral contraceptives
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of the gut microbiome after a 4-week supplementation period | Change from Baseline Gut Microbiome at 4 weeks | \- To assess the profile of gut flora (% abundance of various bacterial phyla, families, genera and species) at baseline and after supplementation in ultra-endurance athletes, using a 16S ribosomal RNA sequencing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in blood markers of exercise-associated oxidative stress (8-isoprostaglandin 2Fa, Total Antioxidant Capacity, and Total Oxidant Capacity in plasma) | 4 weeks | \- Blood samples were collected pre-and post-exercise applied before and after supplementation to evaluate the change in exercise-induced oxidative stress in plasma. Plasma concentrations of 8-isoprostaglandin 2Fa, Total Antioxidant Capacity, and Total Oxidant Capacity were analysed using ELISA kits. |
Countries
Turkey (Türkiye)
Outcome results
None listed