The Relation Between Abdominal Obesity, Type 2 Diabetes Mellitus and Knee Osteoarthritis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04779164

Enrollment

126

Registered

2021-03-03

Start date

2020-09-04

Completion date

2020-10-30

Last updated

2021-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Keywords

knee osteoarthritis, type 2 diabetes

Brief summary

Background:Knee osteoarthritis is more common in patients with type-2 diabetes mellitus, however it is not known whether this effect is caused by diabetes itself or concominant abdominal obesity. Objectives:The aim of this study is to determine whether type-2 diabetes itself, independent of abdominal obesity, is a risk factor for femoral cartilage, knee osteoarthritis and poor quality of life. Design:A cross-sectional design. Settings:Training and research hospital in Turkey. Patients and Methods:Female patients was enrolled in this study and divided into two groups: according to presence or absence of diabetes. Later, both the patients with and without abdominal obesity was divided into two groups according the presence of diabetes. Main Outcome measures:Clinical parameters were visual analog-scale, gait speed and short form-36. Knee radiographs were evaluated according to Kellgren Lawrance-Scale. And ultrasonography parameters were the measurements of distal femoral cartilage thickness. Sample size:126

Interventions

DIAGNOSTIC_TESTknee ultrasonography

The knees of all patients were screened with ultrasonography device for the measurement of femoral cartilage thicknesses.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

NONE

Intervention model description

Both patients with and without diabetes mellitus was evaluated in terms of pain and ultrasonographic femoral cartilage thickness.

Eligibility

Sex/Gender

FEMALE

Age

40 Years to 70 Years

Healthy volunteers

Inclusion criteria

* being female * aged between 40 and 70.

Exclusion criteria

* Patients with any concomitant chronic disease * rheumatoid arthritis * cardiac diseases (except type 2 diabetes mellitus and hypertension) * knee surgery * trauma * bone mass or cancer * inflammatory arthritis * impaired cognitive status * immobilized patients * type 1 diabetes mellitus

Design outcomes

Primary

Measure	Time frame	Description
Femoral cartilage thickness	baseline	Measured by ultrasonography (higher value:thick cartilage, lower value:thin cartilage)

Secondary

Measure	Time frame	Description
visual analog scale	baseline	pain measurement (point 0 to 10) 0:worse pain 10:no pain
radiographic knee osteoarthritis	baseline	evaluated by kellgren lawrance scale.(0-4) 0:no osteoarthritis, 4: severe osteoarthritis

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026