Estrogen, Phthalate Exposure, Preeclampsia, Progestin
Conditions
Brief summary
Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. Prenatal exposure phthalates would disrupt the level of sex hormone in pregnant women, which results in preeclampsia. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.
Interventions
OTHERtest Phthalates, estrogen and progesterone
test mothers Phthalates in their urine, and test estrogen and progesterone receptor in placental tissue
Sponsors
Second Affiliated Hospital of Wenzhou Medical University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Singleton pregnancy * Term pregnancy with the gestational age of 37-40 weeks
Exclusion criteria
* Maternal systemic diseases (hypertension disorders, immunological diseases) or pregnant complications (polyhydramnios, oligohydramnios, diabetes mellitus, intrahepatic cholestasis of pregnancy) * Delivery before 37 weeks or after 40 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Phthalates in urine | 37 weeks to 40 weeks gestation | Collect the urine of pregnant women and test the abundance of Phthalates |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The female progesterone | 37 weeks to 40 weeks gestation | Collect the placenta tissue of pregnant women and test the abundance of estrogen progesterone receptor |
Countries
China
Outcome results
None listed