Bacterial Infections, Lactate Blood Increase, Viral Infection
Conditions
Brief summary
Acute upper respiratory tract infection(AURI) is common in children, and viral infection is the main cause. However, several children with viral infection are easy to suffer from secondary bacterial infection, and the mechanism is unclear.
Detailed description
Lactate is an important molecule in the spread and metastasis of tumor by suppressing the innate immune response. As is known, the immune system is not mature in children and it is reverse related to the age of children. An reasonable hypothesis is that the lactate is a independent risk factor in the children with viral infection progress to bacterial infection. Here, our aim is to test the hypothesis.
Interventions
OTHERviral infection
a child is infected by virus only
OTHERviral and bacterial infection
a child is infected by virus and progress to bacterial infection
Sponsors
Children's Hospital of Chongqing Medical University
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Minutes to 18 Years
Healthy volunteers
No
Inclusion criteria
* child's age is from 0 to 18 years * a child is at least diagnosed with viral infection
Exclusion criteria
one of the following conditions appeared: * congenital heart disease or other abnormalities * respiratory failure * hereditary and/or metabolic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| level of lactate | three days after admission | level of lactate in both viral and viral and bacterial infection groups |
| the level of lactate dehydrogenase(LDH) | three days after admission | level of LDH in both viral and viral and bacterial infection groups |
Countries
China
Outcome results
None listed