Elderly, Nutrition Poor, Physical Exercise, Sarcopenia
Conditions
Brief summary
This study is aimed to explore the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life in community-dwelling older population.
Detailed description
Objective: This study is aimed to explore the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life in community-dwelling older population. Methods: We conduct a quasi-experimental study to measure frailty, depressive symptoms, and quality of life before and after intervention. A total of 120 community-living older adults with frailty identified by Fried's phenotype method are assigned to four groups: physical exercise group, nutrition supplements group, physical exercise and nutrition supplements group, and control group. Each participants in the assigned group will receive 12 weeks intervention. Measurements include frailty (Fried's phenotype method), depressive symptoms (Geriatric Depression Scale-15, GDS-15), and quality of life (WHOQOL-BREF). Data analyses include describe statistics, Chi-square test, and Analysis of Variance. A Generalized estimating equations (GEE) will be used to examine the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life.
Interventions
BEHAVIORALindividual physical exercise group
The participants in physical exercise group will receiving individual physical exercise lead by physiological therapist for 60 minutes/ three times weekly for 12 weeks.
DIETARY_SUPPLEMENTindividual Branched-Chain Amino Acids supplements group
The participants in nutrition supplements group will receiving Branched-Chain Amino Acids 5 g Branched-Chain Amino Acids every day for 12 weeks.
OTHERcombination of physical exercise and nutrition supplements group
The participants in physical exercise group will receiving physical exercise lead by physiological therapist for 60 minutes/ three times weekly for 12 weeks and 5 g Branched-Chain Amino Acids every day for 12 weeks.
Sponsors
Taipei Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* older adults aged more than 60 years; * pre-frail stage: must have one item as frailty identified using the Fried's phenotype method; * normal cognition: AD8 score less than 2 points; * can communicate with Mandarin or Taiwanese.
Exclusion criteria
* incapable of walk independent or using assistive devices (e.g., crutches); * a condition of having an acute disease, hemodialysis, or unable to engage in physical activity; * have history of unstable heart disease such as coronary heart disease, heart failure and hypertension without regular medication; * have regular physical activity (≥150 minutes weekly) such as aerobic dance, swimming, Tai Chi.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| frailty score | frailty score at baseline | Frailty will examined using Fried's phenotype method and higher score indicates more frailty |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Depressive symptoms score | Depressive symptoms at baseline | Depression will measured using Geriatric Depression Scale-15 (GDS-15) and and higher score indicates more depression |
| Quality of Life score | Quality of Life at baseline | Quality of Life will examined using World Health Organization Quality of Life scale and higher score indicate better quality of life |
Countries
Taiwan
Outcome results
None listed