Blood Loss and Preeclampsia

Does Preeclampsia Affect Blood Loss During a Caesarean Procedure

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04777097

Enrollment

120

Registered

2021-03-02

Start date

2021-01-01

Completion date

2025-02-28

Last updated

2023-12-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Loss, Coagulation Disorder, Pre-Eclampsia; Complicating Pregnancy

Keywords

Pre-eclampsia, blood-loss, impaired coagulation

Brief summary

Study of blood loss in preeclamptic patients using mathematical formulae

Detailed description

Pre-eclampsia is a symptom complex that occurs in 2-5% of all pregnancies and leads to significant morbidity and mortality. It is associated with a risk of impaired coagulation caused by a reduced platelet count, very rarely by disseminated intravascular coagulation disorders. The degree of clotting correlates with the severity of preeclampsia. It is planned to calculate the blood loss using mathematical formulas and to compare the different blood loss in the two groups (preeclampsia vs. healthy pregnant women). Furthermore, this project will try to correlate the blood loss with the underlying coagulation situation. The aim is to be able to better assess the bleeding risk in healthy pregnant women, but also in pre-eclamptic patients in the future.

Interventions

OTHERBlood sample

Two blood sample will be drawn. On the day of operation and the first postoperative day.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Inclusion criteria

* Elective or urgent caesarean section * Written informed consent

Exclusion criteria

* Emergency caesarean section * Familial coagulation disorder * Hematological disorders that affect the platelet count, e.g. myelodysplastic syndrome (MDS) * Taking anticoagulants * Taking aspirin in the last 14 days * Use of NSARs in the last 24 hours

Design outcomes

Primary

Measure	Time frame	Description
Blood-Loss	day 1	Corelation between blood loss and coagulation parameters will be calculated

Secondary

Measure	Time frame	Description
Coagulation parameter	day 1	Impact of pre-eclampsia on the coagulation parameters

Countries

Switzerland

Contacts

Primary ContactMarco P Zalunardo, Prof

marco.zalunardo@usz.ch+41442552695

Backup ContactDonat R Spahn, Prof

donat.spahn@usz.ch+41442552695

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026